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PhD in Target-directed synthesis of protein-protein interaction inhibitors

  • Full or part time
  • Application Deadline
    Friday, December 13, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A fully funded PhD studentship position is available in the group of Dr Anna Barnard in the Department of Chemistry at the White City Campus of Imperial College London.
This project will focus on the target-directed synthesis of protein-protein interaction inhibitors.

Throughout biology, protein functions are critically mediated through interactions with other biomolecules, including with other proteins. The resulting complex array of protein-protein interactions (PPIs) mediates every cellular pathway across all forms of life. Some of the most interesting interactions are key steps in disease progression or are critical for the survival of pathogens such as bacteria, viruses or parasites, making PPI inhibition a promising target for the development of therapeutics. However, targeting PPIs remains a significant challenge due to their large interacting interfaces which possess few well-defined binding pockets.

A potential way to mitigate this would be to allow the protein target itself to select for inhibitors by first covalently tethering a basic scaffold capable of performing bio-orthogonal chemistry which a pool of potential binding groups. This will vastly improve the efficiency of PPI inhibitor generation and provide methodologies which can be applied to targeting any PPI of therapeutic interest.

This project will involve organic chemistry (inhibitor synthesis), protein expression of target proteins and the biophysical analysis of inhibitor activity via fluorescence assays, ITC and SPR along with the development of novel methods for the screening of large inhibitor libraries.

Funding Notes

Candidates should have a Masters level degree at 2.1 level or higher, or an equivalent qualification. Interested candidates should contact for informal inquires.

To apply please send a CV and Cover letter to . Applications are open until December 13th 2019 and interviews will take place in January.

How good is research at Imperial College London in Chemistry?

FTE Category A staff submitted: 54.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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