It is now firmly established that in the mammalian brain neuronal networks cannot successfully perform their functions without concomitant metabolic and signalling support from the adjacent glial cells, called astrocytes. ||Unless astrocytes are engaged, physiological functions of neural networks are compromised [1-4]. Numerous examples of such close interactions include the hippocampal memory storage apparatus, brainstem centres of respiratory and cardio-vascular control, and brain areas involved in regulation of sleep.
But how do astrocytes sense when adjacent neurones are activated? Several theories were put forward over the past years, but none looks sufficiently straightforward and convincing. We hypothesise that the key element to this interaction are receptors for the nucleotide adenosine which are highly expressed on astrocytes across all brain areas. Adenosine can be released directly from neurones or produced extracellularly by enzymatic conversion of ATP, which is also released into the extracellular space when neural circuits are active.
In this project we will try to find out whether adenosine receptors actually underpin some of the previously proposed mechanisms of astrocytes’ activation.
The project will involve imaging, work with primary cultures and/or cultured slices of astrocytes from rodents, potentially metabolomic analysis and molecular biology experiments with viral vectors.
How to apply:
PhD
Please follow the link below and apply to the Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience, selecting the programme "Physiology, Pharmacology and Neuroscience (PhD)".
PhD Physiology, Pharmacology and Neuroscience | Study at Bristol | University of Bristol
MScR
MSc by Research (MScR) is a 1-year research degree that provides an intensive lab-based training and a preparation for PhD study. You will carry out your studies as part of your research group – like a PhD student does. Towards the end of the year, you write up a thesis on your research and are examined on this. This degree suits students wanting to gain maximum research experience in preparation for PhD applications.
We are keen to recruit a diverse range of students and to ensure our research is open to all. We particularly welcome applications from groups traditionally under-represented in life sciences research. Please check the University webpages for the current tuition fee information. Most MScR projects also require a bench fee. This varies depending on the research and your project supervisor can tell you the bench fee for the project.
Please follow the link below and apply to the Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience, selecting the programme "Physiology, Pharmacology and Neuroscience (MSc by Research)".
PhD Physiology, Pharmacology and Neuroscience | Study at Bristol | University of Bristol
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