PhD Position in cardiac protein homeostasis

The position is limited to 3 years. With option of further extension. The salary is paid according to the German TV-L system (the salary agreement for public service employees).

 The group of PD Dr. Ashraf Rangrez is seeking a highly motivated PhD student to fill the position of a DFG-funded project focusing on E3 Ubiquitin Ligases in the heart. Using state-of-the-art experimental approaches and in vitro/in vivo models, our aim is to understand the function of E3 Ubiquitin ligases in cardiac (patho)physiology. Our research team is well experienced in all used methods an clinical models. The group is embedded into an excellent research environment from the department of cardiology with strong collaboration with other research insitutes in Heidelberg. You fit to us if you want to work in a world-class research environment with state-of-the-art equipment and access to comprehensive research facilites. You have the ability to work independently, but also show a strong team spirit.

 Tasks and responsibilities

·      To validate proteomics findings and understand its functional relevance

·      To identify the transcriptional effects by chromatin immunoprecipitation-sequencing (ChIP-Seq) and RNA-sequencing (RNA-seq)

·      To study the cardiac-restricted loss-of-function effects in a conditional knockout mouse

 Prerequisites

·      Masters in Cell Biology / Molecular Biology / Life Sciences/Biochemistry / related subjects

·      A prior hands on experience with routine molecular / cell biology techniques

·      Excellent communication and organizational skills with good knowledge of English language

·      Willingness to work on small animal models (mice, rats), prior experience will be a plus

 We offer you

·      Target-oriented individual further education and training opportunities

·      Targeted training on the job

·      Ticket for public transport

·      Possibility of child care (crèche and kindergarten) as well as subsidy for holiday care for school children

·      Active health promotion

·      Company pension scheme

·      Access to the university library and other university facilities (e. g. university sports)

 We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.

 Interested?

For further Information please contact PD Dr. Ashraf Rangrez via e-mail: [Email Address Removed]

 Application must include a motivation letter, CV, publication list (if any), contact details of two referees and applications will be accepted until 23^rd of August via e-mail or apply online (https://karriere.klinikum.uni-heidelberg.de/stellenangebot/13070/PhD-Position-in-cardiac-protein-homeostasis.html).

 Universitätsklinikum Heidelberg

Zentrum für Innere Medizin

Klinik für Kardiologie, Angiologie, Pneumologie (Innere Medizin III)

PD Dr. Ashraf Rangrez

Im Neuenheimer Feld 410

69120 Heidelberg

 www.klinikum.uni-heidelberg.de/karriere