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  PhD Position on Inflammatory Bone Loss (f/m/x)


   Department of Orofacial Orthopedics

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  Dr Matthias Weider  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Orofacial Orthopedics 25 hours Limited to 36 months Starting: September 1 st , 2024Salary according to German TV-L Application deadline: July 7 th , 2024

The Department of Orofacial Orthopedics (Prof. Dr. Lina Gölz) of the Uniklinikum Erlangen in collaboration with the Department of Medicine 3 (Prof. Dr. Stefan Uderhardt) offer a PhD position in the joint project “Histocytometric and molecular assessment of the inflammatory osteoclastogenic niche in situ” within the Transregio TRR 369 “Degeneration of bone induced by inflammation – DIONE”.

In our clinics, we care for patients suffering from various chronic inflammatory diseases. Pathological inflammation is often accompanied by collateral tissue destruction, e.g. bone erosion, which can lead to structural disabilities or even complete loss of function of the affected tissue in patients. The aim of this project is to understand the mechanisms that lead to emergence of bone-resorbing osteoclasts in model systems for destructive autoimmune diseases, such as inflammatory arthritis and periodontitis. To this end, we will perform transcriptome profiling of immune and non-immune cells during disease progression and use state-of-the-art whole tissue optical imaging and novel AI-driven analysis techniques (3D histocytometry) to probe deep into the tissues and decipher the cellular and molecular processes behind pathological osteoclast formation in situ and in vivo as well as bone remodeling in general.

UKER as an employer

Your tasks

The successful candidate will perform

  • Established model systems for inducible arthritis or periodontitis
  • Quantitative imaging combined with AI-driven analysis techniques
  • Transcriptomic analyses

Essential experience / qualifications

  • Graduation at master level (or equivalent) in biology, immunology, molecular medicine, or a related field of research by the time of application or expected soon

Additional advantages

  • Highly motivated candidate with a background in (molecular) biology and/or immunology who is a strong team player
  • Experience in bioinformatics, imaging techniques, as well as mouse models would be advantageous

We offer

  • A secure, interesting position as part of a motivated, open team
  • A well-equipped lab with access to the newest technologies (e.g. light sheet microscopy, multiplex imaging, computational facilities, transcriptomics)
  • A motivated surrounding embedded in the Transregio TRR 369 DIONE
  • A thorough and qualified induction, and support in your new challenge
  • A structured educational PhD program (graduate school of TRR DIONE)
  • Varied and responsible tasks with individual opportunities to grow and develop as a professional
  • All public service benefits, including supplementary benefits from the Federal and State Government Pension Fund (VBL)
  • Pay grade is determined depending on qualifications and personal requirements according to TV-L
  • We seek to employ at the earliest possible starting date

All benefits at UKER

Information for applicants

Apply Now

Your contact person:

  • Dr. Matthias Weider
  • Laboratory Manager
  • Department of Medicine 3 – Orofacial Orthopedics
  • Phone: +49 9131 85-45653 
Biological Sciences (4) Computer Science (8) Medicine (26)
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 About the Project