The Collaborative Research Centre 1052 “Obesity Mechanisms” was established in 2013 with funding from the German Research Foundation (DFG). The doctoral researcher position is limited to 3 years. The salary is paid according to the German TV-L system (the salary agreement for public service employees).
Supervisors: Dr. Ruth Stassart, Dr. Robert Fledrich
More Details:
About the CRC1052
The Collaborative Research Center 1052 “Obesity Mechanisms” was established in 2013 with funding from the German Research Foundation (DFG). The CRC1052 combines interdisciplinary basic and clinical research across biochemistry, biophysics and chemistry, endocrinology, neuroscience, paediatrics, and cardiology. It aims to provide structured doctoral training centrally aligned in three main research areas – A, Overeating, B, Fat deposition and inflammation, and C, Adipokines. With the successful extension for a 3rd funding period to 2024, we are looking for highly motivated candidates to study the complex and multifactorial disorder mechanisms of obesity.
Aim of the PhD project:
Neuropathy is the most common complication in type 2 diabetes (T2D) and is very frequent already in prediabetic, obese individuals. Neuropathy presents usually symmetrically, develops from distal to proximal, and includes sensory and motor impairment. With further progression, patients may experience severe chronic pain and become wheelchair-bound. Up to now, no cure is available and even glycemic control in patients with T2D does not effect on neuropathy.
Our group focuses on the identification of pathological mechanisms that may provide new targets to treat neuropathy. Within the offered PhD projects, together, we follow the hypothesis that increased circulating leptin levels, as seen in obese individuals, constitutes a risk factor for the development of peripheral neuropathy.
We mainly work with genetically modified mice and offer a broad spectrum of laboratory techniques, including immunostainings, whole tissue clearing, fluorescent and electron microscopy, molecular protein (Western blot) and nucleic acid (qPCR, single cell RNAseq) related methods. The successful applicants will learn how to statistically analyse and visualise obtained data, understand and critically analyse scientific publications, and get interesting scientific input from their colleagues.
Our laboratory comprises two joint working groups, AG Stassart (Paul Flechsig Institute of Neuropathology) and AG Fledrich (Institute of Anatomy), funded by ERC, Emmy Noether grants and DFG (CRC project C10). Although we are goal-oriented and straightforward, we need to keep a harmonic working atmosphere with flat hierarchies. A balanced mix of ~20 MD/PhD students and more experienced MDs/PhDs are waiting to work with you! We would require a student who has a strong interest in neuroscience and basic molecular biology experience.
How to apply
For further information, please contact the lead supervisors, Dr. Ruth Stassart or Dr. Robert Fledrich, before applying [Email Address Removed] / [Email Address Removed]
To apply for the positions applicants should complete the Application form and include a full academic CV, publication list (if any), copies of your degree certificates and contact details of two referees. The applications will be accepted until 15th of September via e-mail to the CRC office [Email Address Removed]
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