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PhD programme in Integrated One Health Solutions in Edinburgh and Leiden - Rapid identification of pathogens utilising MinION technology


College of Medicine and Veterinary Medicine

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Dr K Templeton , Dr Eric Claas No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

• Background
A PhD training partnership has been set up between the Universities of Edinburgh and Leiden in One Health Integrated Solutions. The partnership recruited its first cohort of students in December 2019.
The programme is hosted by the Centre for Inflammation Research in partnership with Edinburgh Infectious Diseases and the Roslin Institute, and one further PhD studentship based in Edinburgh and fully funded for four years focused on Integrated One Health Solutions is now available. This will cover stipend, tuition fee and travel funds.
The aim is to foster collaboration and to build on existing synergies in the identified themes of this call. Our universities have a long record of collaborative research and teaching, in particular in the fields of medicine and infectious diseases.
The additional studentship will complete the initial cohort and ensure each University funds four studentships. This additional studentship will commence in 2021 in areas previously identified where significant joint interest and expertise were identified with evidence of potential cross centre collaboration.
It is envisaged the student will be registered for the degree in the University of Edinburgh and be co-supervised with at least one co-supervisor coming from the University of Leiden. It is the expectation that student will spend time in each institution, with a minimum of 12 months in the University of Leiden.
Information about investigators from Leiden and Edinburgh and the specific projects available in this call, aligned with ‘One Health’, are given below.
Students should identify their first choice project plus a second choice they would consider undertaking – see link to other projects below.

The selection process will involve an interview with members from both institutions.

• About the Project

Rapid identification of pathogens utilising MinION technology

Supervisors: Dr Kate Templeton (Edinburgh) and Dr Eric Claas (Leiden)

Project: Rapid identification of the etiologic agent of an infectious disease is essential for best management, setting up treatment and preventive measures. The current approach requires that specific pathogen identification is performed by direct diagnostic tests which normally include culture and PCR-based assays. Although these approaches are highly specific and well validated, they suffer a number of limitations. In addition many of the current techniques are relatively slow taking several days to deliver results and often are biased to one or two pathogens and don’t capture the complexity of the full microbial picture.
Rapid identification of the etiologic agent of an infectious disease is essential for best management, setting up treatment and preventive measures. The current approach requires that specific pathogen identification is performed by direct diagnostic tests which normally include culture and PCR-based assays. Although these approaches are highly specific and well validated, they suffer a number of limitations. In addition many of the current techniques are relatively slow taking several days to deliver results and often are biased to one or two pathogens and don’t capture the complexity of the full microbial picture.
The aim of this PhD project is to develop a rapid, genome sequence-based, diagnostic approach to optimise management of infections, focussing on (i) Challenging cases; (ii) Rapid delivery at point of impact and (iii) Poly microbial diagnosis.

Complete list of available projects: https://www.ed.ac.uk/edinburgh-infectious-diseases/teaching/phd-programmes/phd-integrated-one-health-solutions

Funding Notes

The successful applicant will be awarded a 4 year studentship, which includes their stipend (UKRI rate), tuition fees and is open to students from any country in the world. Funding covers contributions towards travel, up to 12 months living expenses at the second centre and research costs.

Applicants should hold at least an upper second-class degree or equivalent in a relevant discipline, e.g. immunology, microbiology, biology or fields related to the specific project.

Please submit the following to [Email Address Removed]:

(i) Personal statement
(ii) CV
(iii) Ranking of preferred projects
(iv) Fill the online application form

References

The studentship will be awarded competitively. Applicants should also arrange for two academic referees to submit letters of reference by email to CIR.postgraduate@ed.ac.uk before the deadline.

All documents should be submitted no later than 5pm GMT on 28 October 2020
Short-listed candidates will be notified by email.
Informal enquiries can be sent via email to Dr Kate Templeton Kate.Templeton@ed.ac.uk

Please follow the guidelines on how to apply:
https://www.ed.ac.uk/edinburgh-infectious-diseases/teaching/phd-programmes/phd-integrated-one-health-solutions/how-to-apply





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