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PhD Project in Biophysical Engineering, Biophysics, Physical Chemistry: Antimicrobial peptide double cooperativity towards new antimicrobial agents


   Institute of Industrial Science

   Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

In the laboratory of Biophysical Engineering, the Institute of Industrial Science, at the University of Tokyo, Japan, we have an open project for PhD students.

Project description            

A mixture of different types of biomolecules sometimes boosts or suppresses their activities or even generates a new function known as cooperativity. Recently we have reported a unique cooperative function between two well-known antimicrobial peptides (LL-37/HNP1) that kills bacteria more efficiently while minimizing the host damage by suppressing mammalian cell membrane lysis (Biophysical Journal 2020119 (12), 2440-2450). Such a “double cooperativity” may be used in our immune system and may help with developing efficient and safe antimicrobial agents for the current crisis of antimicrobial resistance.

In this project, to clarify the mechanism of the double cooperative effect, we will challenge mammalian/bacterial cells and their cell membrane mimics by LL-37, HNP1, and their mixture, and will study their responses by biophysical assays based on supported and pore-spanning bilayers, such as fluorescence recovery after photobleaching (FRAP), quartz crystal microbalance with dissipation (QCM-D), electrochemical impedance spectroscopy (EIS), and single-channel conductance measurement.

Please visit our webpage for the details!

Qualifications

Highly-motivated students with any background who are interested in pursuing a research career are encouraged to apply.

How to apply

If you are interested, please send your CV to . Selected candidates will go through an online Interview.


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