Coventry University Featured PhD Programmes
John Innes Centre Featured PhD Programmes
Catalysis Hub Featured PhD Programmes
University of Kent Featured PhD Programmes
University College London Featured PhD Programmes

PhD Scholarship - Sexual conflict and aging (UQ/Exeter Joint PhD)

  • Full or part time
  • Application Deadline
    Monday, May 20, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

At any given age men are more likely to die than women, but women have poorer health at older ages. This is referred to as the “male-female, health-survival paradox” – women live longer but suffer more. This paradox is not driven by selective death as women have higher survival probabilities at every age, but tend to live more of their lives in poorer health.

Our previous work (Nature Communications) used mathematical models and Drosophila flies to provide a general solution to the health-survival paradox based on intra-locus sexual conflict, where alleles segregating in the population have late-acting positive effects on male fitness, but negative effects on female health. However, we know little about variation in the inter-sexual genetic associations, and so whether this solution to the paradox is likely to be general.

This project will address the question of how inter-sexual genetic correlations for life history (reproduction, aging and health) evolve and therefore how easy it is to change the genetic architecture to resolve the inter-sex health-survival trade-off. Results of the study will be of considerable interest to evolutionary biologists, gerontologist and geneticists as studies of this type have never been conducted. The project will provide the student with a range of experiences and skills that will equip them to conduct their own innovative research in either applied areas of biology (including health) or in fundamental research.

In this project, the student will determine the intersexual genetic correlations for lifespan, age-dependent fertility and a marker of late-life health (i.e. healthy aging) across the well-established Drosophila phylogeny to gain insight into how the genetic basis of male and female health and longevity has evolved. To achieve this, the student will take advantage of Professor Hosken and Dr Archer’s knowledge of life history (aging and reproduction), sexual selection and sexual conflict, and access their unique resource of laboratory populations sampled from across the Drosophila phylogeny. Dr McGuigan will then work with the student to train them in the application of sophisticated multivariate analyses to characterise among-species variation in the inter-sex correlations and the within sex correlations among traits.

The student will divide their time between experimental design, theoretical modelling and experimental work at the University of Exeter (Hosken and Archer), and application of complex multivariate quantitative genetic analyses at the University of Queensland (McGuigan).

Funding Notes

This scholarship includes a living stipend of AUD $27,596 (2019) tax free, indexed annually, tuition fees and Overseas Student Health Cover (where applicable). A travel grant of AUD $8,500 per annum, and a training grant of AUD $3,000 are also available over the program.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

FindAPhD. Copyright 2005-2019
All rights reserved.