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PhD student in Biophysics/Physical Chemistry:Investigating the Hydration and Dynamics of the Urea Channel Protein by Means of Fluorescence Spectroscopy and Microscopy

  • Full or part time
  • Application Deadline
    Monday, March 16, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

The position is part of the Innovative Training Network (ITN) “PROTON”. The network is devoted to the investigation of proton transport and proton-coupled transport. It is funded under Marie Sklodowska-Curie actions (H2020-MSCA-ITN-2019, grant agreement number: 860592). The applicant will mostly work in the Department of Biophysical Chemistry (Martin Hof Lab, http://hof-fluorescence-group.weebly.com/), J. Heyrovsky Institute of Physical Chemistry, Prague, Czech Republic.

The successful applicant will investigate the hydration and dynamics of the urea channel protein by means of fluorescence spectroscopy and microscopy. As a part of the project, function-relevant regions of this membrane protein will be modified and the effect of various lipid compositions on its activity will be investigated. The gained results will be correlated with the ability of the protein channel to transport protons yielding new insights into the mechanism of the channel functioning. The PhD student will have two secondments (2 to 3 months each).

Applications

Motivation letter, 2 reference letters, Curriculum Vitae and copies of bachelor and master certificates are needed for the application.

We are offering a full time position for three years. Monthly salary will be approximately €1600 after taxes and social security. The earliest starting date is the 1 April 2020. 25 days paid leave of absence (holidays) and lunch vouchers are included.

Special requirements

1. Applicants must, at the date of recruitment by PROTON, be in the first four years (full-time equivalent
research experience measured from the date when the researcher obtained the degree entitling him/her to
embark on a doctorate) of their research careers.
2. They should not have been awarded a doctoral degree.
3. Applicants must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting institution for more than 12 months in the 3 years immediately before the recruitment date.
4. Knowledge of the English language is essential.
5. The knowledge on the protein purification and reconstitution, fluorescence spectroscopy/microscopy, and programming skills in Matlab are welcome.

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