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  PhD student in cardiac muscle function at the fiber and molecular

   The Institute of Physiology II

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  Prof WL Linke  Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

The Institute of Physiology II, University of Muenster, Germany, is offering a position starting as soon as possible limited to 3 years.

PhD Student (gn*)

Salary according to collective agreement (TV-L), pay scale E 13 (65%)

Reference number: 7020

(*gn=gender neutral)

We are seeking a motivated PhD student interested in cardiac muscle function at the fiber and molecular level to join the Institute of Physiology II at the University of Muenster, Germany, under the direction of Professor Wolfgang Linke . This research group is world-renowned for its work in determining the importance of the muscle sarcomere protein titin under healthy conditions and in the failing heart.

The PhD position is associated with a DFG (German Research Foundation) research project entitled “Decrypting the contribution of titin and other cytoskeletal elements to cardiac force generation at the cellular level” awarded to Dr. Christine Loescher.

The project will use a mouse model to quantify the contribution of titin to passive and active force and ultrastructure stability in relation to other cytoskeletal structures in cardiomyocytes and heart tissue. This will be done using cardiac fibers and isolated cardiomyocyte mechanics as well as EM/IF and live cell fluorescent imaging.

Required qualifications:

Applicants should be motivated and have, or soon obtain, a MSc degree (or equivalent) in cell biology/physiology, biomechanics, or a related field. Applicants should be willing to present research that they will have carried out, preferably culminating in a PhD thesis or first-author research publication. Finally, a high level of English language skills is mandatory (C1 level according to CEFR).

Desired Qualifications:

Candidates with experience in cardiomyocyte physiology are encouraged to apply. Experience with animal handling is a must. Experience with Langendorff, live cell fluorescent imaging, EM/IF imaging, and Western blots are highly desirable. Experience using software packages such as Graphpad prism is also desirable.

We are looking forward to your online-application including the reference number (full CV, supporting statement (500 words max), academic transcript (unofficial OK at this stage) and the name and contact information of at least one referee in a single (!) PDF file) including:

  • Your supporting statement should outline your reasons for wishing to undertake this project, your academic interests and prior research experience.

Due to legal requirements working with us is only permitted with complete vaccination against measles.

Applications of women are specifically invited. In the case of similar qualifications, competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities. Handicapped candidates with equivalent qualifications will be given preference.

The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.

Biological Sciences (4) Medicine (26)
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 About the Project