PhD Student (m/f/d) Cellular Biophysics and Translational Cardiology Section

The Cellular Biophysics and Translational Cardiology Section, together with the Core Facility Proteomics of the UMG offers a position for a:

PhD Student (m/f/d) SFB 1002

limited until 06/24, part time

salary according to TV-L

The University Medical Center Göttingen is a tertiary care center that offers great development potential. It's 7,900 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Situated in Göttingen, the “City of Science” located near the center of Germany, the University Medical Center Göttingen is embedded in the city’s attractive network of scientific research facilities.

The Cellular Biophysics and Translational Cardiology Section at the Heart Research Center together with the Core Facility Proteomics offer a research position for a highly motivated PhD student. The PhD project “Proteomic analysis of local molecular membrane nanodomain function in cardiomyocytes” is part of the Collaborative Research Center CRC 1002, a competitive and highly interdisciplinary large-scale collaborative project funded by the german research foundation:
https://www.dfg.de/en/funded_projects/current_projects_programmes/list/projectdetails/index.jsp?id= 193793266&sort=nr_asc&prg=SFB

Beat-to-beat cardiomyocyte function depends on proteins in nanodomains at the level of the sarcolemmal surface membrane and the sarcoendoplasmatic reticulum that control local metabolic functions. Caveolins are membrane shaping proteins typically associated with caveolae in muscle cells. Recent investigations identified novel protein / protein interactions for specific caveolin isoforms that stabilize specific metabolite transport functions at the sarcolemmal surface and in transverse tubule membrane compartments.

The goal of the project is to establish the underlying mechanism of action of subcellular protein clustering and interactions using biochemistry, proteomics mass spectrometry and high-resolution imaging approaches. Of particular interest are human caveolin mutations and molecularly defined loss-of-function mechanisms which affect cardiomyocyte function. The student will work with human iPSC cell models, mouse models including primary isolated cardiomyocytes and therapeutic interventions to define cardiac disease mechanisms. As part of the project, he / she will employ advanced mass spectrometry and superresolution microscopy techniques in a highly interdisciplinary setting.

The candidate will be located at the Heart Research Center Göttingen and participate in the campus-wide CRC 1002 and IRTG 1816 activities.

What you will be doing:

• Applying and optimizing state-of-the-art protein-protein interaction biochemistry protocols, high-resolution subcellular (co-) localization imaging and analysis, analyzing mass spectrometry data in samples ranging from cultured cells to cardiac tissue samples.

• Building and applying your collaborative networking and scientific portfolio through associated cardiovascular research projects in the CRC 1002.

Who you are:

• A highly motivated PhD candidate with a drive to learn and excel in science. You like to communicate with scientists and enjoy working in a highly interdisciplinary, multicultural research environment.

Your background ranked according to relevance:

• Protein biochemistry; cell and molecular biology; high-resolution imaging and ideally mass spectrometry.

Desirable training:

• Protein biochemistry (WB, pull-down), protein and peptide separations (SDSPAGE, HPLC), confocal and superresolution microscopy; mass spectrometry, statistical data analysis.

What our group offers:

• An exciting collaborative research environment with state-of-the-art methods and equipment at the University Medical Center Göttingen.

• Our group has established advanced techniques in mass spectrometry-based proteomics and high-resolution imaging. Our experience in methods teaching in interdisciplinary teams will provide you with the knowledge and skills you need to carry out successful experiments.

• A competitive scientific project embedded in a research center with plenty of opportunities to interact and learn from researchers from various disciplines.

• Scientific retreats and conferences are part of your work and provide opportunities for scientific networking and collaborations.

• Direct interaction with an active proteomics and imaging research community in Göttingen.

Your application should include in one single PDF file:

• A cover letter explaining your motivation and abilities specifically for the advertised position.

• A current CV including the PMID identifiers of any (co-) authored papers.

• At least two reference letters from previous supervisors dated in the same month as applied.

Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
We look forward to receiving your application by August 8th, 2020:

University Medical Center Göttingen
Clinic for Cardiology and Pneumology
Prof. Dr. S. Lehnart
37099 Göttingen
Tel.: 0551/3963631
Fax: 0551/39-63713
E-Mail: [Email Address Removed]
Web: https://herzzentrum.umg.eu/forschung/arbeitsgruppen/zellulaere-biophysik-undtranslationale-kardiologie/

Please send your application via e-mail in PDF-format or via mail in copy and not in folders.

Travel and application fees cannot be refunded or transferred.