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PhD student (m/f/d): Personalizing the diagnosis, prognosis and treatment options for patients with these hematologic neoplasias

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  • Full or part time
    Dr B Chapuy
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The Clinic of Hematology and Oncology, the group of Professor Dr. med. Björn Chapuy offers a position for:

PhD student (m/f/d)
limited (3 years), full time position, salary according to TV-L

The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7,900 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, located near the center of Germany, the University Medical Center Göttingen is embedded in the city’s attractive network of scientific research facilities.

Aggressive B-cell lymphomas are the most common lymph node cancers in adults and are characterized by clinical and molecular heterogeneity. The Chapuy laboratory ( aims to personalize the diagnosis, prognosis and treatment options for patients with these hematologic neoplasias. Using functional and integrative genomics and epigenetics as well as other cutting edge technologies (Monti,Chapuy et al. Cancer Cell 2012; Chapuy Cancer Cell 2013; Chapuy et al., Blood 2016a; Chapuy et al., Nat Med 2018; Chapuy et al., Blood 2019) the workgroup elucidates coordinate genetic signatures of B-cell lymphomas with discrete biology that extend our unique understanding of the molecular heterogeneity of aggressive B-cell lymphomas at diagnosis and its change during treatment. The extracted coordinate genetic signatures yield testable hypotheses for subsequent mechanistic studies in in vitro and in vivo model systems, provides opportunities for the development of novel modeling approaches such as patient-derived xenograft models (Chapuy et al, Blood 2016b) and eventual translation in the clinics, such as PD-1 blockade in B-cell lymphomas (Ansell et al., NEJM 2015; Nayak et al. Blood 2017). Here we are explicitly looking within a Jose Carerras Research grant in a joined project with the Jose Carreras Leukemia Research Institute in Barcelona, Spain, for a dedicated molecular biologists with a deep understanding of normal and/or pathological B-cell diseases and a very strong interest in functional epigenetics with the eventual goal to exploit novel treatment avenues for subsets of lymphoid malignancies.

We solicit applications from highly motivated candidates that hold either a master or equivalent degrees from life sciences such as biology, molecular medicine etc., preferentially with experience in hematologic malignancies and/or epigenomics. The successful candidate is an experienced master student in life sciences. The candidate has a stellar track record as evidenced by either publications, international experiences and/or successfully applied for independent funding. Candidates with no more than ½ year from graduation as master are encouraged to apply. The successful candidate has a profound knowledge and hands-on-experiences in genomics and/or epigenetics, functional testing and associated interrogation of signaling and survival pathways in eukaryotic cell culture systems and excels in a wide variety of molecular- and cell biology methods. Work with mammalian cell systems is essential. Besides wet lab skills, the successful candidate need to be willing to learn analyzing (epi)genomics data. Coding skills are not needed at time of application but the willingness to learn would be essential. The ability to plan and work independently is equally essential as summarizing the work in presentations. To this end, the successful candidate has to have a track record of presentations at meetings. A passionate and professional work attitude is expected.

The successful candidate must work in our international team of scientists, train and overview younger researchers, including medical students and undergraduate. To this end, the candidate is an excellent team player and is an excellent communicator. Candidates with a clear academic track are preferred. Fluency in written and spoken English is mandatory.

PhD students receive in addition to their wages also social benefits, that includes participation in a health plan for the candidate and his/her family and the accumulation of retirement benefits.

Interested candidates must submit their application composed of a curriculum vitae and a letter of motivation via E-mail to [Email Address Removed] before April 30th.

At least two reference contacts should be listed and/or reference letters should be included in the application.

Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by April 30th, 2020:

University Medical Center Göttingen
Klinik für Hämatologie und Medizinische Onkologie
Prof. Dr. med. Björn Chapuy
37099 Göttingen
Tel.: 0551/39-7075
Fax: 0551/39-8587
E-Mail: [Email Address Removed]

Prof. Dr. Björn Chapuy

Please send your application only via E-mail as a PDF-file.

Travel and application fees cannot be refunded or transferred.

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