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PhD student (m/f/d): Uncertainty Quantification in Models of Implant Degradation

  • Full or part time
    Ms E Krüger
  • Application Deadline
    Tuesday, October 08, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

Reference code: 50003329_1
Commencement date: This PhD position is initially limited to 3 years, starting date latest 1st November 2019.
The place of employment is Hamburg (DESY), in Germany.

Research at HZG in the field of “Metallic Biomaterials” focusses on the development of biodegradable Mg-based alloys and implants by the optimization of mechanical, biological and degradation properties for specific applications. To this end, it is crucial to understand the mechanisms governing the interactions between microstructure, mechanical properties, biology and degradation. In the long run, such understanding will enable the manufacturing of implants tailored to the specific needs of individual patients. One part of this is the understanding of Mg degradation and influence of specific organic and inorganic components, as well as the uncertainty introduced by in vitro measurements.

You will be responsible for developing a mathematical model of the degradation of Magnesium and Mg alloys that will determine the influence of specific organic and inorganic components on the degradation process. Experimental data on degradation rates, chemical composition of the degradation medium and the evolving degradation layer, and resulting pH on the electrochemical processes will be used as input and validation data. Furthermore, as part of the Helmholtz-Incubator network “Uncertainty Quantification”, you will quantify and analyze the model uncertainty in terms of its output parameters. In the long term, this model shall serve as an alternative to experimental techniques to enhance the reduction of required in vitro experiments prior to animal experiments. You will work closely with other PhD students and post-docs in the Helmholtz Incubator network, which will develop a unified library for UQ that will be applied to the different research questions within the network.

Your tasks

• gathering all relevant data from previous experiments and literature
• development of the mathematical model of Mg degradation in salt solutions
• quantify the uncertainty introduced by measurements used for input and validation
• if needed, initiate specific experiments to gain missing data

Your profile

• university degree (MSc, Diploma or equivalent) in mathematics, data / computer science, natural sciences or engineering
• strong analytical skills and sound theoretical background
• experience in Multiphysics modelling is appreciated
• experience in statistical methods is appreciated
• background knowledge in the field of electrochemistry is appreciated
• team spirit, excellent communication and organization skills, fluent English

We offer

• multinational work environment with over 950 colleagues from more than 50 nations
• extensive options of vocational training (i. a. expert seminars, language courses or leadership seminars)
• flexible working hours and various models to ensure the compatibility of family and career
• excellent infrastructure, including a scientific in-house library as well as modern work spaces
• remuneration according to the standards of the collective wage agreement TV-AVH including further social benefits
• you will work in a team of several computational scientists and experimentalists who can provide data along the full chain from material design up to in vivo data

The promotion of equal rights is a matter of course for us. Severely disabled persons and those equaling severely disabled persons who are equally suitable for the position will be considered preferentially within the framework of legal requirements.

The Helmholtz-Zentrum Geesthacht is one of the 19 national institutions of the Hermann von Helmholtz Association of German Research Centres e.V. (HGF). Around 950 employees carry out basic research and development work in close cooperation with national and international research institutions, research-oriented clinics and economic and public institutions.

At the Institute of Materials Research some 200 scientists conduct research in the five sub-institutes "Materials Mechanics", "Materials Physics", "Materials Technology", "Magnesium Innovation Centre MagIC" and "Metallic Biomaterials".

Application deadline: 08.10.2019
Job location: Hamburg
Contact: Ms. Erika Krüger

Apply Now:¶m=cG9zdF9pbnN0X2d1aWQ9MDA1MDU2ODIyRkE2MUVEOUIyQjEzQjZBODlEQTc5RDAmY2FuZF90eXBlPQ%3d%3d&sap-client=002¶ms=cG9zdF9pbnN0X2d1aWQ9MDA1MDU2ODIyRkE2MUVEOUIyQjEzQjZBODlEQTc5RDA%3d#

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