The Clinic for Dermatology, Venerology and Allergology offers as soon as possible a PhD student position (f/m/d) in a research project analyzing the "Communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system" limited for 3 years, 19,25 h/week (50%)
salary according to TV-L
The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 8,100 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, located near the center of Germany, the University Medical Center Göttingen is embedded in the city’s attractive network of scientific research facilities.
Cells of the innate immune system communicate with each other and with cells of the adaptive immune system to orchestrate immunologic responses. Communication between cells influence important cellular functions such as apoptosis, production of neutrophil extracellular traps (NETs) and collective cell behavior. Interestingly, the signaling molecules that neutrophilic granulocytes use to communicate with each other, are poorly characterized.
The goal of this project is to assess how neutrophils produce and release these signaling molecules, which receptors are engaged on the neutrophil surface and which biological effects certain signaling molecules have in neutrophil biology. Additionally, we will investigate interactions between neutrophils and other cells of the immune system such as B- and T-cells.
Prospectively, the project can be extended to encompass the interactions between neutrophils and tumor cells, particularly melanoma cells, as neutrophils appear to play a pivotal role in tumor-immunology.
We have a strong focus on microscopy (including life-cell imaging, confocal microscopy and reflection interference microscopy), physical methods such as atomic force microscopy (AFM), as well as nanotechnology-based methods to detect signaling molecules in real-time and at a very high spatial and temporal resolution. Cell culture techniques, working with primary human cells and patient samples as well as murine models will also be part of this project.
Settled at the interface of immunology, medicine and biophysics, this project will be supervised by Dr. Luise Erpenbeck, MD (Dpt. of Dermatology, Venerology and Allergology) in cooperation with Dr. Sebastian Kruss, PhD (Institute for Physical Chemistry, Göttingen, Homepage: http://www.uni-goettingen.de/de/512667.html
). Dr. Erpenbeck’s research focuses on innate immunity in inflammatory diseases, while Dr. Kruss has a long-standing interest in biophysical aspects of cellular behavior and on nanothechnology.
The student will be enrolled in one of the GGNB graduate programs (Molecular Medicine, Neurobiology or Physics of Complex Biological Systems).
the possibility to work on an interdisciplinary, cutting-edge project
two well-equipped, modern laboratories with state-of-the-art technology
a highly motivated research team
motivation to solve complex biological problems
a strong interest in learning methods new from different disciplines
the ability to think outside the box and to combine results from different fields
Master or Diploma in biology, physics, biophysics, biochemistry or a similar disciplin
Men are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
We look forward to receiving your application by December 31st, 2019:
University Medical Center Göttingen
Clinic for Dermatology, Venereology and Allergology
Dr. med. Luise Erpenbeck
E-Mail: [email protected]
Please send your application only via e-mail as a PDF-file.
Travel and application fees cannot be refunded or transferred.