The Institute for Auditory Neuroscience of the University Medical Center Göttingen (Germany) invites applications for a PhD student position in Synaptic Neuroscience limited for 3.5 years, part-time (65 %) salary according to TV-L.
The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7,900 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, located near the center of Germany, the University Medical Center Göttingen is embedded in the city’s attractive network of scientific research facilities.
• Strong background in sensory neuroscience
• Experience in electron microscopy advantageous
• Excellent English skills
• Completed university studies in a life science discipline (MSc or diploma)
Cochlear inner hair cell (IHC) ribbon synapses are specialized structures that are crucial for the conversion of acoustical information into neural signals. Defects in transmission cause hearing impairment – auditory synaptopathy. We investigate the dynamic nanostructure of synaptic vesicle pools at ribbon synapses in IHCs of wildtype and mutant mice. In the proposed project, we analyze exocytosis phases at IHC ribbon synapses by the usage of temporally precise stimulation through optogenetics. This we will combine with high-pressure freezing (HPF)/freeze-substitution and subsequent electron tomography. We will precisely stimulate IHCs of channelrhodopsin2 mice crossbred with KOs for different presynaptic key players in order to understand the influence of these different presynaptic proteins in parameters such as synaptic vesicle number or how they are linked to the active zone.
The offered PhD project is founded by the German Research Foundation (DFG, CRC 889, “Cellular Mechanisms of Sensory Processing”) and is part of the Molecular Architecture of Synapses Research Group of the Institute for Auditory Neuroscience at the Center for Biostructural Imaging of Neurodegeneration (BIN). The position is available for 3+ years. Income is equivalent to E13/65 %.
The Göttingen Campus is a leading neuroscience center in Europe hosting numerous prestigious and internationally renowned neuroscience research institutions. This includes the University, three Max Planck Institutes, the European Neuroscience Institute and the German Primate Center, as well as further collaborative research programs.
Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
We look forward to receiving your application by March 6th, 2019:
University Medical Center Göttingen
Institute for Auditory Neuroscience
Dr. Carolin Wichmann
Tel.: +49 551 39 61128
Fax: +49 551 39 12950
E-Mail: [email protected]
Please send your application only via e-mail as a PDF-file.
Travel and application fees cannot be refunded or transferred.