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PhD student position (m/f/d) in biochemistry and structural biology

About This PhD Project

Project Description

The Cluster of Excellence „MULTISCALE BIOIMAGING: From Molecular Machines to Networks of Excitable Cells (MBExC)” invites applications for a PhD student position (m/f/d) in biochemistry and structural biology available for 3 years, 65 % | salary according to TV-L

The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7,900 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, located near the center of Germany, the University Medical Center Göttingen is embedded in the city’s attractive network of scientific research facilities.

The position will be based within the newly established lab of Julia Preobraschenski in the Institute for Auditory Neuroscience at the University Medical center. The goal of the lab is to unravel the molecular mechanisms underlying the multi-C2-domain protein family of ferlins, as well as their alterations in human disease. The focus of the project will be the characterization of the family member dysferlin, which plays a critical role in membrane repair and is linked to muscular dystrophy (Lek et al. (2012) Traffic). To that end we will employ multidisciplinary approaches, including state-of-the-art biochemical and biophysical methodologies and single particle cryo-electron microscopy (see e.g. Preobraschenski et al. (2018) Cell Rep.; Farsi et al. (2016) Science; Preobraschenski et al. (2014) Neuron).

We are looking for excellent and highly motivated applicants with background in biochemistry or structural biology. Cryo-EM experience is a plus but not required.

The Preobraschenski lab is part of the Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable cells” (MBExC). MBExC is an interdisciplinary, cross-faculty research center of the University of Göttingen and pursues a novel research approach with joint efforts in modern bioimaging, in particular photonics, molecular biosciences, neuroscience and cardiovascular research. The goal of MBExC is to decipher disease relevant nanoscale functional units in neurons, sensory cells and cardiomyocytes with the long-term goal to develop innovative therapeutic strategies for disorders affecting the heart and the brain, or both. By a multiscale bioimaging approach, MBExC aims at unraveling fundamental biological principles at an increasing level of complexity from molecular, nanoscale to network and organ levels. The MBExC research program covers gene expression and regulation, protein assembly and targeting, Ca2+ signaling and Ca2+ triggered membrane fusion as well as the development of innovative research techniques.

MBExC relies on a close interdisciplinary collaboration between the University Medical Center Göttingen the faculties of Chemistry, Physics, Mathematics and Biology of the University and the non-university research institutions in Göttingen, such as the German Centre for Cardiovascular Research e.V. (DZHK), the German Center for Neurodegenerative Diseases e.V. (DZNE) and the Max Planck Institutes for Biophysical Chemistry, of Experimental Medicine and for Dynamics and Self-Organization.

Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by December 31th, 2019:

University Medical Center Göttingen
Cluster of Excellence Multiscale Bioimaging (MBExC) Dr. Julia Preobraschenski
Robert-Koch-Str. 40
37075 Göttingen
Tel.: 0551/201-1714

Please send your application via e-mail in PDF-format or via mail in copy and not in folders.

Travel and application fees cannot be refunded or transferred.

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