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PhD student / Research Fellow in Biophysics / Molecular and Cell Biology


   Institute of Systems and Physical Biology

   Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

There is an opening for a PhD student in the field of single-molecule biophysics / molecular and cell biology.

You are invited to join the team of the principal investigator, Dr. Artem Efremov (www.artem-efremov.org; https://www.szbl.ac.cn/scientificresearch/researchteam/394.html) at Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, which is doing experimental and theoretical studies of molecular complexes responsible for cell mechanosensing and nuclear organization in living cells in collaboration with Southern University of Science and Technology and Hong Kong University.

This is a full-time position. The starting date is flexible, but ideally the project should begin in 2022.

Project description

Recent development of single-molecule biophysical methods has made it possible to apply mechanical forces to subcellular organelles and even individual molecules with a high spatial and temporal resolutions. This resulted in discovery of the major role of mechanical forces in regulation of multiple biomolecular interactions in living cells, which use such a regulation to sense and actively respond to changes in the mechanical properties of extracellular matrix and forces existing in it. Yet, despite a large number of newly identified mechanosensing protein complexes discovered during past several years, molecular mechanisms by which they contribute to regulation of cell behaviour in many cases remain poorly understood.

By utilizing a multidisciplinary approach based on use of single-molecule techniques, such as optical and magnetic tweezers, as well as confocal imaging of living cells and advanced theoretical modelling, we aim to investigate in our laboratory the main molecular mechanisms responsible for: 1) transduction of extracellular mechanical cues into cell signalling cascades responsible for regulation of cell migration, and 2) spatial organization of chromatin in nuclei of living cells.

Several examples of past experimental and theoretical studies that has been done by us can be found via the following web-links:

https://www.nature.com/articles/s41467-019-10964-w

https://www.biorxiv.org/content/10.1101/2020.10.21.346247v1

https://www.jbc.org/article/S0021-9258(20)35072-9/fulltext

https://academic.oup.com/nar/article/46/13/6504/5033546?login=true

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.94.032404

Duties and responsibilities

•  Develop and implement a scientific project by using single-molecule and single-cell manipulation techniques based on magnetic and optical tweezers experimental setups.

•  Collaborate with other research teams within the institute as well as with international collaborators from other countries.

•  Write scientific papers, present results at national and international conferences.

Qualifications and experience

•  A Ph.D or Master degree in life sciences / biophysics / biomedical engineering / or related disciplines is required.

•  Both fresh graduates as well as research fellows are welcome to apply.

•  We are looking for both experimental and theoretical researchers.

•  For experimental researchers experience in microscopy imaging, or image analysis, or mammalian cell culturing would be advantageous.

•  For theoretical researchers experience in chemical kinetics theory, or statistical physics, or polymer physics would be beneficial.

Salary

Research Fellow salary: 300k-400k RMB annually, commensurate with qualification and working experience.

PhD student salary: 150k-250k RMB annually, commensurate with qualification and working experience.

Application procedure

•  Interested applicants please send your English CV (with the names and contacts inside, together with e-mail addresses of two referees) to Artem Efremov via e-mail:


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