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PhD Studentship, Alzheimer’s Society

  • Full or part time
  • Application Deadline
    Tuesday, January 14, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A 3-year fully-funded PhD position is available through the Alzheimer’s Society scheme in UK Dementia Research Institute at the University of Cambridge.

The project aims to identify the components of the intrinsic cellular machineries for handling aggregation-prone proteins, and characterise circumstances in which these machineries are activated, with the view to identifying new therapeutic targets to ameliorate/prevent the aggregation load in neuronal cells (associated with neurodegenerative diseases). The project stems from in-house developed technology enabling detection of failures in the protein-folding quality control system with high space-time resolution, and its ability to visualise the existence of the aggregation-resolving activity in live cells.

Student will develop the experimental models for monitoring protein quality control and aggregation in live iPSC-derived neurons, and analyse the activity of the intrinsic systems applying a range of biochemical, molecular biology and advanced light imaging techniques. Along with molecular biology/biochemistry, the work will involve training in light microscopy techniques such as Fluorescence Lifetime Imaging, super-resolution microscopy and single particle tracking using state of the art optics and software. This work will be conducted with support of interdisciplinary collaborators including physicists and computer scientists, enabling optical tools, mathematical modeling and data analysis.

The successful student will develop skills in biochemistry, cell biology, molecular biology, and advanced microscopy and image analysis. Students from disciplines other than biological sciences, who have a numeric aptitude and a strong interest in developing those skills are welcome to apply too (an academic background in mathematics, statistics, or computer science would be of interest).

The student will be based in the UK DRI, Department of Clinical Neuroscience, Clifford Allbutt Building, at the Cambridge Biomedical Campus. The supervisor’s research group is an interdisciplinary team studying organelle biology in neuronal cell function and neurodegeneration, supported by a network of international and local collaborations.

Funding Notes

fully funded 3 year PhD covering Home/EU fees and maintenance

further job details can be found here; View Website

Related Subjects

How good is research at University of Cambridge in Clinical Medicine?

FTE Category A staff submitted: 192.05

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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