PhD Studentship: Developing a bioinspired drug delivery system to accelerate musculoskeletal regeneration

We are seeking a highly motivated candidate to work on a PhD project that seeks to exploit natural cell-derived extracellular vesicles (EVs) for the delivery of a range of therapeutic molecules for musculoskeletal regeneration. The prospective candidate will develop and optimised protocols for EV loading and validation. They will also investigate the effects of loaded EVs on musculoskeletal metabolism and function.

Loughborough University is a top-ten rated university in England for research intensity (REF2014). In choosing Loughborough for your research you will l work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.

Find out more: http://www.lboro.ac.uk/study/postgraduate/supporting-you/research/

The School of Sport, Exercise and Health Sciences has been ranked 1st in the world for Sport-related Subjects (QS World University Rankings by Subject 2017, 2018, 2019 and 2020).
Full Project Detail
Extracellular vesicles (EVs) function as specialised and secure nano-compartments for the targeted delivery of a wide variety of signalling molecules throughout the body. Recent evidence suggests that within the musculoskeletal system EVs mediated signalling to maintain bone homeostasis and tissue integrity. However, the biochemical properties that dictate how these complex nanoparticles are selectively shuttled between cells remain undefined. In this project we will seek to define and hijack the natural targeting properties of EVs for the delivery of pro-therapeutic molecules that can be applied to enhance fracture healing and improve musculoskeletal regeneration.
Find out more
https://www.lboro.ac.uk/departments/ssehs/staff/owen-davies/
Entry requirements
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in biochemistry, pharmacology or a molecular biology subject. A relevant Masters degree and/or experience in one or more of the following will be an advantage: analytical science, drug/biomolecule encapsulation, practical cell culture experience, musculoskeletal biology.
How to apply
All applications should be made online at http://www.lboro.ac.uk/study/apply/research/. Under programme name, select “School of Sport, Exercise and Health Sciences”.

Please quote reference number: SSEHS/OG
Start date of studentship: 01 October 2020
Closing date of advert: 17 July 2020
Interview date: August 2020