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  PhD Studentship in Artificial Cell Engineering and Bioinspired Technologies

   Department of Chemical Engineering

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  Dr Yuval Elani  Applications accepted all year round  Competition Funded PhD Project (Students Worldwide)

About the Project

PhD Studentships in Artificial Cell Engineering and Bioinspired Technologies

The Elani Group in the Department of Chemical Engineering at Imperial College London welcomes applications for a PhD studentship to conduct work in the area of Artificial Cell Engineering and Bioinspired Technologies. We have secured fully-funded positions to conduct research in any of the group's research areas. These scholarships are open to both home and international students, and cover stipend, tuition fees and consumables. The position is for 3.5 years with an October 2024 start. Applicants should hold or expect to obtain a First-Class Honours or a high 2:1 degree at Master's level (or equivalent) in a relevant Science or Engineering degree. 

About our research

Biological cells, at their core, are simply a complex web of interacting molecules. Given this, we can ask the questions: what if we could create entirely artificial cells from scratch? Can we make life from inanimate matter? And can we engineer artificial cells as micromachines that perform bespoke functions in industrial and clinical settings?

Answering these questions will pave the way for disruptive applications, transform our understanding of biology by building a new biology, and shed light on the philosophical question of what it means for something to be alive.

In recent years, the Elani group have been at the forefront of the emerging research area of artificial cell engineering. Instead of re-programming living cells, we engineer biology from the molecule up by controllably bringing together both biological and synthetic building blocks (lipids, enzymes, membrane channels, DNA, nanoparticles etc). We are exploring the use of synthetic cells as smart drug delivery agents, biosensors, cell therapies and as tools in pharmacokinetic screens. We are increasingly interested in fusing living cells with synthetic ones, to construct hybrid 'cellular bionic' systems.

In this PhD, the candidate will develop new technologies to generate synthetic cells, and engineer them to possess the behaviours that are the hallmarks of life: motility, energy generation, communication, replication, decision-making, and self-repair. These synthetic cells will be designed to solve pressing challenges in healthcare, being used in sensing, diagnostic and therapeutic applications.

A project could involve designing and working with engineered bio-membranes, cell-free protein expression systems, functional nanoparticles, as well as microfluidic technologies. This will be a multi-disciplinary project which, depending on the applicant's background and research interest, will span across one or more of chemical biology, synthetic biology, soft matter, membrane biophysics, molecular bioengineering and microfluidics. We can tailor the project based on the candidate's skillset and interest.

We are open to explore a project collaboratively with successful candidates. Some ideas of the project we would like to work on include:

·       Building a biomimetic anti-cancer micromachine

·       Microfluidic assembly of massive nanoparticle libraries: a disruptive paradigm for particle discovery and bio-nanotechnology 

·       Design rules for remote controlled biology: activation of synthetic cells using stimuli-responsive nanoparticle organelles

·       Bioengineered sensors for disease detection and in-situ therapeutic responses 

·       Chemical biology approaches for synthetic organelle construction

·       Real-time genetic reprogramming of micron-scale soft matter devices 

Getting in touch

If you are interested in applying, please send a CV and a motivation letter to Yuval at . Feel free to get in touch or visit my group and personal websites if you would like more information.

Biological Sciences (4) Chemistry (6) Engineering (12)
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 About the Project