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PhD Studentship in Biosciences: No ESKAPE: targeting an outer membrane protein complex in pathogenic bacteria to overcome antimicrobial resistance.

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  • Full or part time
    Prof B Van Den Berg
    Dr J Hubbard
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Number of awards
1

Start date and duration
28 September 2020.
The funding covers a three year PhD.

Overview
Are you interested in the global problem of antimicrobial drug resistance and do you want to contribute towards the development of novel antibiotics? This project will study an essential membrane protein complex of Gram-negative bacteria with the goal to identify small molecules that will inhibit the formation of the protective layer on the bacterial surface.

The outer membrane (OM) LptDE complex found on the surface of many important Gram-negative pathogens plays an essential role in bacterial survival by mediating assembly of the lipopolysaccharide (LPS) outer layer of the OM. Its surface location, and the fact that it is essential in most Gram-negative pathogens, makes LptDE an extremely attractive target for antibiotic drug discovery. In this project you will identify small molecules that may form the basis for future novel antibiotics.

Besides standard microbiological, molecular biological and protein biochemical techniques, you will receive training in (membrane) protein structure determination by X-ray crystallography (and potentially cryo-EM) and biophysical approaches.

Sponsor
Newcastle University

Name of supervisor(s)
Professor Bert van den Berg - https://bit.ly/2WRxfdP
Dr Julia Hubbard

Eligibility Criteria
You must have, or expect to achieve, at least a 2:1 Honours degree in biomedicine, biochemistry, microbiology or a related area. A further qualification such as an MSc or MRes is advantageous.

This award is available to UK/EU and international applicants.

To study this course you need to meet the following English Language requirements:
IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).

How to apply
You must apply through the University’s online postgraduate application system https://bit.ly/2xtQbVF.

Only mandatory fields need to be completed. However, you will need to include the following information:

-insert the programme code 8300F* in the programme of study section
-select ‘PhD in the Faculty of Medical Sciences – Biosciences’ as the programme of study
-insert the studentship code bi020 in the studentship/partnership reference field
-attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code bi020 and state how your interests and experience relate to the project
-attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications

* The online application system will only allow one application using the programme code 8300F. If you are applying for TWO or more projects using that code then you will need to email our Postgraduate Admissions Service ([Email Address Removed]) with the following information:

-your application number (from the first project application that you submitted online)
-the second studentship code and its corresponding title
-a two page covering letter for the second project

Our Postgraduate Admissions Service will then forward this information to the relevant selector in the Faculty of Medical Sciences.

Contact
Professor Bert van den Berg https://bit.ly/2WRxfdP
Biosciences Institute https://bit.ly/3bwPFEX
E-mail: [Email Address Removed]

Funding Notes

100% of UK/EU tuition fees paid and annual living expenses of £15,285 (full award). Successful international candidates will be required to make up the difference between the UK/EU fees and international fees.



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