Project Description:
We are seeking to appoint a PhD research student to join the translational Lymphoma Immunology group led by Dr Alan G. Ramsay. The group aims to identify effective combination immunotherapy and mechanisms of action within the tumour microenvironment/TME. In addition, we study and model the role of fibroblasts and endothelial cells within lymphoid tissue TMEs, as well as clinical trial-associated biomarker and bioassay studies to help advance the design of future therapies for patients.
Immunotherapy response rates have been disappointingly low in many B cell malignancies that develop within lymphoid tissues (chronic lymphocytic leukaemia, diffuse large B-cell lymphoma). This has highlighted the need to understand immunosuppressive mechanisms within these tumours (TMEs). The PhD project is a NIH-funded, USA clinical trial-associated correlative science project to identify bioassays/-markers for developing immunotherapy.
This post represents a unique opportunity for an ambitious scientist to develop their scientific career and make significant contributions to an exciting and translationally focussed field with mentorship by Dr Ramsay and team.
The post will be based at Guy’s Cancer Centre, London Bridge allowing access to exceptional core laboratories including tissue culture (to model tumour, immune and stromal cell cultures), the Nikon Imaging Centre @ King’s (advanced confocal imaging) and the NIHR BRC Flow Cytometry and Genomics cores (high dimensional analysis facilities).
Application deadline: Applications are open until a suitable candidate is found.
https://www.kcl.ac.uk/research/lymphoma-immunology
Recent publication from group:
Ioannou N, et al. Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy. Blood. 2021 (Cover image and Commentary)
Apollonio B, et al. Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy. Front Oncol. 2021.
Eligibility Criteria:
This is a funded project for European/UK students only. Please note that students must be eligible for fees at the Home rate.
English Language requirements can be found on our online page here.
Application Process:
All candidates must apply through King's application portal King’s Apply.
Application deadline: Applications are open until a suitable candidate is found.
Course - Cancer and Pharmaceutical Science Research MPhil/PhD (Full-time)
Interested applicants are encouraged to contact Dr Ramsay ([Email Address Removed])
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