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PhD Studentship in Mineralomics of Cardiac Diseases - Ref: 1820830

  • Full or part time
  • Application Deadline
    Thursday, November 07, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The Department of Medical Physics & Biomedical Engineering at UCL is inviting applications for a studentship on Mineralomics of cardiac diseases.

The Department is proud to host internationally-leading research groups covering a broad range of activities and spread over several sites. Our staff and students have a diverse range of interests and expertise, covering many areas of physics, engineering, medicine, physiology, computer science, and mathematics. This provides a highly stimulating multidisciplinary environment for learning and for scientific research.

The Department holds an Athena Swan Bronze Award which recognises and celebrates good practice and commitment to advancing women’s careers in science, technology, engineering, math’s and medicine (STEMM) in higher education and research. The award reflects our commitment to the advancement and promotion of diversity and equality.

For further information, please visit:
https://www.ucl.ac.uk/medical-physics-biomedical-engineering/about/athena-swan

Studentship Description

We are pleased to offer a research student position open to enthusiastic science graduates. The research project to be completed by the PhD candidate is related to the study and development of cell cultures associated to minerals and the effect of these on cell behaviour and programing. In this project, we will use state-of-the-art electron microscopy and biochemistry techniques to study how cells interact with minerals and characterize these minerals. The nano architecture and, more particularly, the knowledge of which proteins and cell organelles the mineral is interfacing at the nano scale, can tell us whether the mineral is indeed part of the disease mechanism or a by-product of the disease or perhaps even the cause of that disease.

In the last couple of years, we have developed a methodology to culture cells in the presence of calcified particles isolated from cardiovascular tissues. Calcification will be assessed by traditional biochemical and material characterization methods. This project will be carried out in close collaboration with several groups within the Department of Medical Physics and Biomedical Engineering and with the group of Dr Adrian H. Chester from the Faculty of Medicine, National Heart & Lung Institute, Imperial College London.
The PhD student will actively take part in the development of the project, sample collection and preparation, experimental measurements, analysis of the data and interpretation of results.

For further information, please visit: https://www.mineralomics.org/

This is a project involving experimental research, where laboratory experience is a plus. Initially, the project will make extensive use of cell culture and electron microscopes, with new techniques added as the research work progresses. The PhD candidate will be expected to collect and process animal and human tissues.

Person Specification

Applications will remain open until a suitable candidate is found. Applicants must have or expect to obtain either an MSc or a UK first class or 2:1 honours degree or the international equivalent in the appropriate background in biology, medicine, chemistry or materials science.

[Eligibility]]
If you have any scientific queries please contact Dr Sergio Bertazzo at: .
Applications (including a covering letter, CV and names of two referees) should be sent to Miss Mohini Nair at: who will also be happy to handle any informal enquiries
.
Further information on the research is available at http://www.ucl.ac.uk/medphys/research/elt

Funding Notes

Funding will be for 3 years, with a tax free stipend of £17,625.33 total over 3 years and UK/EU-level university fees.

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