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PhD Studentship in Molecular Cell Biology: Membrane Organelle Homeostasis in Health and Disease

MRC Laboratory for Molecular Cell Biology

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Dr C Stefan No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

Applications are invited from academically and technically gifted young scientists for a PhD studentship in Molecular Cell Biology at the Laboratory for Molecular Cell Biology (LMCB). The LMCB is an intellectually stimulating research institute within UCL dedicated to research aimed at understanding the fundamental basis of cell behaviour relevant to human disease.

The candidate will participate in an exciting research programme in Dr Christopher Stefan’s laboratory investigating vital roles of inter-organelle contacts in membrane organisation and homeostasis. Numerous metabolic and neurodegenerative disorders are linked to disruptions in membrane integrity and organelle homeostasis. This project will investigate novel mechanisms for inter-organelle crosstalk and how cells sense and respond to membrane stress. The Stefan research group employs cross-disciplinary approaches including advanced cell imaging (using state-of-the-art membrane lipid biosensors), biochemical (lipidomics and proteomics), biophysical (protein-membrane interactions), and computational approaches. A long-term goal is to translate our findings to identify new molecular targets and strategies for the treatment of diseases caused by alterations in membrane homeostasis.

To learn more about the Stefan research group, please click on the link below.

The position is funded for three years and includes money for travel to conferences. Training is an integral part of the studentship and the successful applicant will have access to a wide variety of courses/tutorials and workshops run by experts in various fields of cell and molecular biology.

Candidates should have a BSci degree or equivalent and an MSci or equivalent would be desirable. Research experience in a cell biology laboratory, knowledge of membrane trafficking and organelle homeostasis pathways would also be desirable, as would demonstrated knowledge and coursework in cell biology and biochemistry.

Prospective applicants are encouraged to contact Chris Stefan [Email Address Removed] to discuss the project.

Applications should be sent to Lucy Newman ([Email Address Removed]) and include a current CV, names and contact information for two references, and a statement detailing why you want to carry out a PhD in the Stefan lab. Please note that applications will only be accepted from candidates who meet the criteria for fees at the UK/EU rate.

Closing date for applications is December 1st 2020 and interviews will be held in December 2020.

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