About the Project
This project is a collaboration between the Institute of Nuclear Medicine (INM) at UCL, the UK National Physical Laboratory and Mediso, the manufacturer of the only commercial clinical tri-modality system (available at NPL). The 4 year studentship, funded by EPSRC and NPL and Mediso, includes a stipend commencing at £19000 plus full university fees (for UK students). Additional funding for travel, conference attendance and consumables is available.
The student will be aligned with the UCL the i4health CDT and benefit from a wide range of activities and opportunities. Imaging facilities at INM include PET-CT, SPECT-CT and PET-MRI scanners.
This project aims to improve the accuracy and precision of clinical functional imaging using joint information from Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET) and x-ray Computed Tomography (CT). PET and SPECT are two of the main imaging modalities for cancer detection and are also used for the detection of inflammation and calcification. They also play a fundamental role in the newly established Theragnostic approach delivering patient-specific treatment and therapy monitoring using images. For the first time, the synergistic reconstruction methods developed in this project will fully exploit the data obtained from triple modality scanners. In addition, we will investigate the possibility to jointly reconstruct data from SPECT/CT and PET/CT scans acquired at different time points. Our aim is to increase the ability of these modalities to early detect and diagnose priority diseases, and to monitor therapy effectiveness.
The project will be mostly related to method development but will include some experiments using phantoms, both at UCL and NPL. We will also have access to patient data of some theragnostic clinical studies. The student will extend current methods for guided and synergistic reconstruction, implement the algorithms in our open source image reconstruction framework, evaluate the performance based on mathematical analysis, numerical simulations and clinical impact.
For more information regarding the project and the research group, please contact Prof Kris Thielemans (firstname.lastname@example.org) or Dr Daniel Deidda (email@example.com) and visit the following websites:
UCL Institute of Nuclear Medicine: https://www.ucl.ac.uk/nuclear-medicine/research/
EPSRC Centre for Doctoral Training in Intelligent, Integrated Imaging In Healthcare (i4health) https://www.ucl.ac.uk/intelligent-imaging-healthcare/
UCL Graduate Prospectus: http://www.ucl.ac.uk/prospective-students/graduate/
UCL Campus information: https://www.ucl.ac.uk/prospective-students/study-abroad-at-ucl/life-ucl/campus-and-facilities
National Physical Laboratory: https://www.npl.co.uk/medical-physics/nuclear-medicine
Applications should be sent directly to Prof Kris Thielemans by email with subject-line “trimodality PhD application” and include a Curriculum Vitae (CV) and a cover letter. This should set out your previous academic or other experience relevant to the proposed research; why you wish to undertake this research at UCL; your previous research or professional training and what further training you think you will need to complete a PhD; and what ethical issues you will need to consider in undertaking this research. In addition, two references should be named at the end of the statement. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.
Candidates must meet the UCL graduate entry requirements which include holding at least an upper second class degree or equivalent qualifications in a relevant subject area such as physics, biomedical engineering, computer science or applied mathematics. A Master’s degree in a relevant discipline and additional research experience would be an advantage. Applicants should have a demonstrated interest in medical imaging.
Applicants whose first language is not English are required to provide evidence of proficiency in English by UCL.
Eligibility follows standard research council rules, and normally include ordinary residence within the UK for 3 years prior to the funding commencing, although this might be relaxed for exceptional candidates. More information can be found on the EPSRC website at: https://epsrc.ukri.org/skills/students/guidance-on-epsrc-studentships/eligibility/
Applications should be sent directly to Prof Kris Thielemans by email with subject-line “trimodality PhD application” and include a Curriculum Vitae (CV) and a cover letter.
Contact name: Kris Thielemans
Contact details: firstname.lastname@example.org
Closing Date: 22 Mar 2021
Latest time for the submission of applications: 23.59
Interview date: TBC
UCL Taking Action for Equality
Eligibility follows standard research council rules, and normally include ordinary residence within the UK for 3 years prior to the funding commencing, although this might be relaxed for exceptional candidates.
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