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PhD Studentship in the School of Natural and Environmental Sciences - Synthesis of antibody-peptide conjugates for imaging and therapy of cancer

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  • Full or part time
    Dr J Knight
    Prof M Waring
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Number of awards:
1

Start date and duration:
September 2019 for 4 years.

Overview:
An exciting opportunity has arisen for a fully funded PhD position within the group of Dr. James Knight in Chemistry, School of Natural and Environmental Sciences at Newcastle University.

Our group’s research interests are embedded in the multidisciplinary field of translational cancer research with special focus on the chemical synthesis and evaluation of new radiopharmaceuticals to assist in the diagnosis, characterisation and treatment of cancer. We are particularly interested in antibody agents due to their favourable target binding properties, and a major focus of our work involves chemically modifying antibodies to allow them to readily internalise into cancer cells.

The aim of this studentship is to explore ways in which cellular internalisation of antibodies can be further enhanced and to develop synthetic methods for the production of these newly-designed agents. As such it will provide ideal training in molecular design and chemical synthesis as applied to biologically active agents. The successful applicant will also evaluate the performance of these new cell-internalising antibodies in a variety of preclinical tumour models which will involve techniques such as radioligand cell-based assays, fluorescence microscopy, and imaging techniques. The studentship provides an opportunity to join an emerging research group at an exciting time when new research projects are being established.

This project will suit chemistry or biochemistry graduates (and those from related disciplines) and would particularly suit a candidate with interests in molecular imaging and/or cancer.

Sponsor:
School of Natural and Environmental Sciences (https://bit.ly/2UoSkYe)

Name of supervisor(s)
Dr James C Knight (https://bit.ly/2Pd84gd) and Professor Mike Waring (https://bit.ly/2UXJtRV), Newcastle University (https://bit.ly/2Pe2pq2).


Eligibility Criteria:
You should have an upper-second-class Honours degree or higher, or international equivalent, in chemistry, biochemistry, or any related discipline. You must meet the English Language Proficiency Requirement (IELTS of at least 6.5 or equivalent).

The award is available to UK/EU applicants only. Depending on how you meet the EPSRC’s eligibility criteria, you may be entitled to a full or a partial award.

How to apply:

You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’ (https://bit.ly/2PeI6Ja).

All relevant fields should be completed, but fields marked with a red asterisk in the application portal must to be completed. The following information will help us to process your application. You will need to:

insert the programme code 8100F in the programme of study section
select ‘PhD Chemistry (full time) - Chemistry as the programme of study
insert the studentship code NES020 in the studentship/partnership reference field
attach a covering letter and CV. The covering letter must state the title of the studentship, quote reference code NES020 and state how your interests and experience relate to the project
attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.

Funding Notes

Full UK/EU fees (eligibility criteria apply to EU students) and annual living allowance of £15,009 (at the 2019/20 UKRI rate).



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