PhD Studentship in Understanding adenovirus diversity and immunity for pandemic preparedness

About the Project

Applications are invited for a fully funded 4-year PhD Studentship in Understanding adenovirus diversity and immunity for pandemic preparedness, based in the Department of Genetics at Cambridge University under the supervision of Dr Charlotte Houldcroft.

Scientific area

Adenoviruses (AdVs) are human pathogens associated with respiratory disease and gastroenteritis. Adenoviruses can recombine their three major surface proteins to form new combinations which evade existing immunity and allow the virus to infect new tissue types. They are also ancient viruses, infecting humans for at least 30,000 years; and they are widespread in wild great apes. The combination of these factors – recombination, long-term success as a human and ape pathogen, and the potential for zoonotic spillover – give adenoviruses significant pandemic potential.

In the Pathogen Dynamics Unit within the Department of Genetics, Houldcroft group undertakes two major strands of adenovirus research: genomics of AdVs in clinical settings, and adaptive immunity to AdVs. Prospective PhD students could therefore tailor a project in two directions.

1.     Bioinformatic analysis of adenovirus genomes from clinical settings around the world. This project will involve long and short read sequencing of AdVs, followed by phylogenetic and population genetics approaches to understanding the diversity and evolution of enteric adenoviruses, using samples from the UK, continental Europe, and Kenya, collected over the last 50 years. The Department of Genetics is home to the University of Cambridge’s Bioinformatics Training Facility.

2.     Characterising the impact of adenovirus evolution on the immune response of blood donors to changes in viral surface proteins. This project will study the adaptive (T cell and antibody) immune response to diverse respiratory AdVs, including adenovirus lineages identified in ancient DNA. Techniques will include ELIspot, ELISA, and virus neutralisation assays.

Candidate Requirements

We are seeking a highly motivated candidate with:

• A First or Upper Second-Class UK Honours degree (or international equivalent) in Biology.
• Strong analytical or experimental skills, with the ability to work independently in a supportive research environment.

Why Join Us?

As part of this studentship, you will:

• Be at the forefront of research in viral genetics and immunology.
• Work with leading experts and innovative technologies in a supportive academic environment.
• Have the opportunity to present your work at international conferences.
• Gain valuable skills for careers in academia, industry, or policy.

The Department of Genetics: https://www.gen.cam.ac.uk/

Group website: https://www.gen.cam.ac.uk/research/research-groups/houldcroft-group

Why Cambridge?

The University of Cambridge offers an inspiring environment for research, with a rich academic tradition, world-class facilities, and a supportive community. As part of the Department of Genetics, you will join a diverse and vibrant cohort of students and researchers working on some of the most pressing questions in science.

How to apply

For more information, please contact Dr Charlotte Houldcroft by email [Email Address Removed] before applying. Please email a CV and a cover letter explaining your motivation to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

A formal application must be submitted by 7th January 2025 through the Cambridge University Applicant Portal (https://www.postgraduate.study.cam.ac.uk/courses/directory/blgepdphg) for the course "PhD in Genetics" commencing October 2025, naming Dr Charlotte Houldcroft as potential supervisor. Interviews are likely to take place in January 2025. See also https://www.gen.cam.ac.uk/postgraduate/postgraduate-apply