PhD Studentship in Unravelling chromatin composition and interactome in ESKAPE pathogens

About the Project

Applications are invited for a fully funded 4-year PhD Studentship in Unravelling chromatin composition and interactome in ESKAPE pathogens, based in the Department of Genetics at Cambridge University under the supervision of Dr Antoine Hocher.

 Scientific area

Across the tree of life, genomes intimately associate with proteins to form chromatin. These interactions are central to genetic and epigenetic processes. Contrasting with their biological and societal importance, little is known about chromatin in bacterial pathogens, even in the highly virulent and antibiotic resistant ESKAPE pathogens.

Building on previous work [1,2], this project aims at the systematic study of chromatin composition in major bacterial pathogens. This will be achieved by combining state of the art nucleoid composition profiling by proteomics, to large scale protein-protein interaction screens using alphafold/alphapulldown.

The study will generate an unprecedented overview of nucleoid composition and chromatin interactors across pathogens. It has the potential to identify key regulatory networks that govern pathogenicity and antibiotic resistance.

Training 

The individual will learn techniques in molecular microbiology, proteomics and computational biology. This project includes both experimental ‘wet lab’ and computational ‘dry lab’ components. There will be opportunities to present at international conferences and to access excellent training sessions offered by the University of Cambridge. The Genetics Department is a fantastic environment that hosts a diversity of topics which are ideal for fostering creativity during a PhD.

Candidate Requirements

We are seeking a highly motivated candidate with:

• A First or Upper Second-Class UK Honours degree (or international equivalent) in Genetics, Biology, or a related field.
• Strong analytical and collaborative skills, with the ability to work independently in a supportive research environment.

Why Join Us?

As part of this studentship, you will:

• Be at the forefront of research in genetics.
• Work with leading experts and innovative technologies in a supportive academic environment.
• Have the opportunity to present your work at international conferences.
• Gain valuable skills for careers in academia, industry, or policy.

The Department of Genetics:

https://www.gen.cam.ac.uk/

https://www.gen.cam.ac.uk/staff/dr-antoine-hocher

Why Cambridge?

The University of Cambridge offers an inspiring environment for research, with a rich academic tradition, world-class facilities, and a supportive community. As part of the Department of Genetics, you will join a diverse and vibrant cohort of students and researchers working on some of the most pressing questions in science.

How to apply

For more information, please contact Dr Hocher by email [Email Address Removed] before applying. Please email a CV and a cover letter explaining your motivation to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

A formal application must be submitted by 7th January 2025 through the Cambridge University Applicant Portal (https://www.postgraduate.study.cam.ac.uk/courses/directory/blgepdphg) for the course "PhD in Genetics" commencing October 2025, naming Dr Antoine Hocher as potential supervisor. Interviews are likely to take place in January 2025. See also https://www.gen.cam.ac.uk/postgraduate/postgraduate-apply