PhD Studentship - Investigating a Novel Genetic Cause of Cardiomyopathy
Number of awards
Start date and duration
28 September 2020. 3 Year PhD
Interested in discovering novel ways to cure heart disease? This project will investigate the genetic mechanisms underlying heart failure using state of the art gene editing technologies to model the patient mutation and how this might be rescued using therapeutic interventions.
We have identified a genetic mutation in a patient with dilated cardiomyopathy and generated transgenic models to assess the impact of this mutation. We hypothesise that the affected gene plays a vital role in mitochondria function within the heart and experiments will be performed to investigate this. For this multidisciplinary project we will combine a wide variety of in vivo and in vitro laboratory techniques, to investigate the underlying molecular mechanisms that cause the cardiac phenotype. Rescue experiments will be performed to discover possible therapies which will have the potential to treat patients with cardiomyopathy. The student will be trained in all the required techniques and have the opportunity to present their data at national and international conferences.
Name of supervisor(s)
Dr HM Phillips (https://bit.ly/33La2vn), Newcastle University Biosciences Institute (https://bit.ly/3akGkzP)
Dr SD Bamforth (https://bit.ly/39k3S6L), Newcastle University Biosciences Institute (https://bit.ly/3akGkzP)
You must have, or expect to achieve, at least a 2:1 Honours degree in biology, genetics, biomedicine or a related area. A further qualification such as an MSc or MRes is advantageous.
This award is available to UK/EU and international applicants.
To study this course you need to meet the following English Language requirements:
IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).
How to apply
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’ (https://bit.ly/2QLajco).
Only mandatory fields need to be completed. However, you will need to include the following information:
insert the programme code 8300F* in the programme of study section
select ‘PhD in the Faculty of Medical Sciences – Biosciences as the programme of study
insert the studentship code BI013 in the studentship/partnership reference field
attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code BI013 and state how your interests and experience relate to the project
attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications
* The online application system will only allow one application using the programme code 8300F. If you are applying for TWO or more projects using that code then you will need to email our Postgraduate Admissions Service ([Email Address Removed]) with the following information:
your application number (from the first project application that you submitted online)
the second studentship code and its corresponding title
a two page covering letter for the second project
Our Postgraduate Admissions Service (https://bit.ly/2wBbvs5) will then forward this information to the relevant selector in the Faculty of Medical Sciences.
For further details please contact:
Dr Helen Phillips
Email: [Email Address Removed]
Telephone: +44 (0) 1912418698
Dr Simon Bamforth
Email: [Email Address Removed]
Telephone: +44 (0) 1912418764
100% of UK/EU tuition fees paid and annual living expenses of £15,285 (full award). Successful international candidates will be required to make up the difference between the UK/EU fees and international fees.