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PhD Studentship – Investigating neuronal injury responses in tau-mediated neuronal degeneration

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  • Full or part time
    Dr K Deinhardt
    Prof Vincent O'Connor
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Alzheimer’s disease and other neurodegenerative disorders are characterised by accumulation of misfolded protein aggregates. Formation of these aggregates triggers an early injury response in neurons, which occurs prior to structural and functional decline and modulates the sequence of neuronal disintegration. The aim of this PhD studentship is to investigate these neuronal injury pathways associated with degeneration induced by misfolded tau protein. The student will characterise the in vivo injury response by analysing tissue derived from a well-defined mouse model of tauopathy. This will be followed by a careful characterisation of the cell biological basis of the injury signal in primary neuronal cultures in vitro, and manipulation of these pathways to distinguish causation from correlation. The studentship is funded by the Alzheimer’s Society, and involves an opportunity for interaction with an industrial partner.

Funding Notes

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend of £ 15,000 per annum.

Due to funding restrictions this position is only open to UK/EU applicants


Applications for an MPhil/PhD in Biological Sciences should be submitted online at :

Please place Katrin Deinhardt’s name in the field for proposed supervisor.

General enquiries should be made to Vincent O’Connor ([email protected]) or Katrin Deinhardt ([email protected]). Any queries on the application process should be made to [email protected]

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified.

The University of Southampton and the Centre for Biological Sciences both hold an Athena Swan Bronze Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

How good is research at University of Southampton in Biological Sciences?

FTE Category A staff submitted: 34.80

Research output data provided by the Research Excellence Framework (REF)

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