Organ fibrosis is the process of tissue scaring and is the pathological consequence of chronic tissue damage and ageing. Cellular senescence (CS) is a process by which cells lose their ability to replicate and instead express inflammatory proteins that are collectively known as the senescence associated secretory phenotype (SASP). In a normal healthy tissue CS is thought to promote wound repair, however in ageing and chronic disease accumulation and spread of senescence (via the SASP), can cause chronic sterile inflammation and fibrosis.
In this project the student will explore the mechanisms linking CS to tissue inflammation and fibrosis using a novel human precision cut liver (PCLS) and kidney (PCKS) slice technology and test the ability of senolytic and senomodulatory molecules to inhibit fibrosis.
The student will join leading team of researchers in the Newcastle Fibrosis Research Group and Biosciences institute. During the project the student will acquire a deep knowledge of the biology of CS and fibrosis alongside developing laboratory-based skills in complex tissue culture, cell and molecular biology and general laboratory practice. The student will be encouraged to attend scientific meetings to develop their scientific knowledge and communication skills.
Number Of Awards
19 September 2022.
3 year PhD
Newcastle University and Fibrofind Ltd
Professor Derek Mann, Dr Lee Borthwick and Dr Gavin Richardson
You must have, or expect to achieve, at least a 2:1 honours degree or international equivalent, in a subject relating to biomedical sciences, biological sciences or a related area. Further qualification such as an MRes is advantageous.
This award is available to home and international applicants. Successful international candidates will be required to make up the difference between the home fees and international fees.
Successful EU applicants will be considered for the Vice-Chancellor’s EU Research Scholarship.
English Language requirements: IELTS 6.5 overall, with 5.5 or more in each sub-skill.
How To Apply
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’.
Only mandatory fields need to be completed. However, you will need to include the following information:
• insert the programme code 8420F in the programme of study section
• select ‘PhD Biosciences (FT)’ as the programme of study
• insert the studentship code BI053 in the studentship/partnership reference field
• attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code BI053 and state how your interests and experience relate to the project
• attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.
Prof Derek Mann