This is a 3 year fixed term post funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement n°814244. The position is available within the Innovative Training Network on BonePainII (www.bonepain.eu).
Osteoporosis is the most common metabolic bone disease and the major cause of fragility fractures. Using a mouse model, we previously demonstrated that fracture-induced pain is severe and can last long after the fracture has healed. The objectives of this PhD are to 1) compare pain behaviours in control and osteoporotic mice during the different phases of fracture healing and correlate them with bone mineral density, architecture, bone remodeling, bone marrow fat, markers of inflammation and peripheral nerve activation; 2) investigate gene expression changes in dorsal horn and fracture callus tissues of control and osteoporotic mice after fracture surgery; 3) compare the effects of NSAIDs, bisphosphonates and anti-Nerve Growth Factor on bone pain relieve after osteoporotic fractures in this model.
We are seeking highly motivated students with a relevant MSc degree. Experience in bone biology and/or chronic pain research will be an advantage. English language proficiency and good general communication skills are expected.
Applicants must be Early-stage Researchers (ESRs and not have resided or carried out their main activity (work, study, etc.) in the UK for more than 12 months in the 3 years immediately prior to the time of recruitment-unless as part of a procedure for obtaining refugee status under the Geneva convention.
The successful candidate will join a collaborative group of researchers in the Comparative Biomedical Sciences Department of the Royal Veterinary College (RVC). The RVC is located in central London with a strong research environment and excellent facilities. It also benefits from its closeness to other institutions nearby, allowing for interactions and collaborations with a large number of research programmes
Prospective applicants are encouraged to contact Prof. Chantal Chenu email: [email protected] tel: +44 (0) 207468 5045.
For further information and to apply on-line please visit our website: http://www.rvc.ac.uk Ref. CBS-0017-19
Closing date: 15 March 2019 Interviews are likely to be held in May 2019
c. £34.6K to £36.9K per annum inclusive of London Weighting