Despite recent therapeutic advances, there are ~26 million patients worldwide (1 million in the UK) estimated to suffer from heart failure, and 5-year mortality associated with the disease is currently reaching 50% in the UK. To improve our therapies against heart failure, new treatments beyond targeting neurohumoral activation and/or cardiac rhythm disturbance are required, which are only possible by increasing our understanding of the basic biology that underlies the disease.
We recently described the cardioprotective effects of the mitochondrial unfolded protein response (UPRmt) in the failing heart. This project is designed to delineate the molecular mechanisms via which the UPRmt exerts its protective effects in the stressed heart. Knowledge obtained from this project can be used to design next generation candidate interventions against heart failure.
Supervisor: Dr Ioannis Smyrnias
This is a 3-year project starting in January 2022.
Entry requirements
Essential
- BSc degree or European equivalent in a relevant discipline (i.e. biological sciences, biomedicine, physiology, medicine)
- Previous experience with cell culture techniques
- Previous experience with fundamental molecular biology/biochemistry and imaging techniques (i.e. working with DNA/RNA samples, real time PCR, western blotting, immunofluorescence)
- Excellent communication and organisational skills
- Ability to work independently and as part of a team
Desirable
- MSc or MRes degree in a relevant discipline (i.e. biological sciences, biomedicine, physiology)
- Previous experience with cardiac physiology research projects
- Previous experience with isolation of primary cells
English language requirements: IELTS Academic 6.5 overall with at least 6.0 in any component.
How to apply
Applications should be submitted via the Veterinary Medicine PhD programme page on the "Apply" tab.
Please state clearly the studentship project at you would like to apply for.
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