Avian colibacillosis, caused by Avian pathogenic Escherichia coli (APEC), is an economically important infectious disease of domestic poultry. Diseased poultry flocks frequently require treatment with antibiotics, but resistance to first line antibiotics is increasingly common and thus of further concern is the emergence of multi-drug resistant APEC strains in poultry.
As an alternative to antibiotics, innate immune mechanisms especially macrophages could be trained to rapidly respond to bacterial infections enabling adaptive immune response to control the disease. In mammals, it has been shown that innate immunity can obtain memory which is termed “trained immunity”, in which the trained innate immune cells such as macrophages can respond to pathogens more rapidly and effectively. However, the role of trained innate immune cells in the control of avian pathogens has not been explored and compounds which could induce the trained immunity in avian cells have not been described. Recent studies in Professor La Ragione’s laboratory have demonstrated that APEC can be classified into number of phylogroups and this may be associated with their virulence potential. Moreover, it is apparent that some serotypes provide excellent cross protection whereas others do not. The proposed studies aim to bring together Professor La Ragione’s bacteriology expertise with Dr Behboudi’s avian immunology to better understand how different APEC strains interact with the chicken immune system.
In this project, the student will examine the differential ability of different phylotypes of APEC to modulate the anti-microbial properties of chicken macrophages, with the aim to establish any possible association between pathogenesis of different strains and their ability to subvert antimicrobial function of macrophage. Moreover, the student will identify non-antibiotic chemical compounds to improve the antimicrobial function of chicken macrophages against highly pathogenic APEC strains.
This is a four year project, commencing in October 2020.
This studentship is open to science graduates with, or who anticipate obtaining, at least a 2:1 or equivalent in a relevant biological subject in their undergraduate degree, or a Masters degree - subject to university regulations. Other first degrees, e.g., veterinary science, will be considered. Experience in bacteriology and immunology will be an advantage. You should be looking for a challenging, interdisciplinary research training environment and have an active interest in the control of infectious diseases.
Students without English as a first language must provide evidence that they meet the English language requirement, e.g. with an IELTS score of 7.0 and no less than 6.5 in any of the subsections
How to apply:
Students should apply through the Veterinary Science PhD programme: https://www.surrey.ac.uk/postgraduate/veterinary-medicine-and-science-phd
Applicants are required to send a cover letter explaining their interest in the project, a CV with relevant qualifications and prior expertise in areas relevant to the project. Two references should be sent directly by your referees. At least one reference should be from an individual with good knowledge of the applicant’s academic record, especially in projects/dissertations.
Suitable interview dates will be directly arranged with shortlisted applicants.