We invite applications for a 3-year PhD studentship in the MRC Centre for Environment and Health and National Institute for Health and Care Research (NIHR) funded Health Protection Research Unit (HPRU) in Environmental Exposures and Health.
Our researchers are uniquely placed to produce high quality research, working with partners to translate knowledge into policy and improve population health, supported by a bespoke training programme to ensure they are equipped with the appropriate skills and experience.
We are seeking an outstanding candidate for a PhD in “Environmental drivers of epigenetic ageing”:
Ageing is one of the principal risk factors for non-communicable disease and the decline in physiologic function. It is well established that epigenetic mechanisms lie at the heart of the ageing process.
Age-associated DNA methylation profiles predict age-related diseases and mortality risk and are used as a marker to assess biological ageing. Epigenetic ageing may therefore underlie associations between air pollution and age-associated disease.
In this PhD we wish to examine whether long-term exposure to urban air pollution, particularly that derived from traffic emissions, promote these age-related changes in DNA methylation profiles.
This PhD studentship (from October 2022) will be supervised by Dr Ian Mudway and Dr Oliver Robinson, Imperial College London, and will align with the Children’s Health in London and Luton and Airwave cohorts.
A strong background in molecular sciences and bioinformatics would be desirable prerequisites for this project, which aligns with the Molecular Signatures and Disease Pathways theme within the MRC Centre for Environment & Health and the Air Pollution and Health, Biomarkers of exposure and effect within the Health Protection Research Unit in Environmental Exposures and Health.
For more information, and instructions on how to apply, visit here.
The MRC Centre and the NIHR HPRUs are committed to equality of opportunity, eliminating discrimination and creating an inclusive working environment.
Studentships will commence by October 2022