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PhD Studentship Opportunity in Multiscale investigation on the role of quantum effects in the spontaneous mechanism of DNA repair

Project Description

The purpose of this research project is to investigate the role of quantum effects on the mechanisms of DNA repair by applying a multiscale computational approach based on a QM/MM methodology.

The first process we will be looking at is the mechanism of DNA self-repair, in which an C-C adduct between two adjacent thymine (T) residues is formed by the photoactivated reaction of DNA under UV irradiation. The thymine dimerisation is one of the major contributions to the mutagenic power of sunlight. In the self-repair mechanism, the DNA strands are localised and broken by an electron-induced reaction that might involve a transient electron-transfer from a neighbouring guanine (G).

We will focus on simulating the role of vibrations in carrying thermal energy from the DNA chain to the reactive site (TT dimer) as well as the dynamics of charge transfer from G to TT. The charge transfer will be investigated by quantum mechanical simulations of the molecular orbitals involved in the reaction and their time evolution at various temperatures, with and without the presence of aqueous solvent.

Entry requirements:
Second class or above in a BSc or MChem or equivalent degree in Chemistry, Physics, or biophysics would be desirable. Experience in Molecular Orbital calculations and knowledge of Protein and DNA structure would be helpful. Applicants who have an A Level or equivalent in Mathematics, Physics or Engineering will be at an advantage. A willingness to work across the disciplines is essential.
If English is not your first language, you will be required to have an IELTS Academic of 6.5 or above (or equivalent), with no sub-test score below 6.

How to apply:
Applications can be made through our Biosciences and Medicine Course page
Please state the project title and supervisor clearly on all applications.

Funding Notes

All University fees are covered for the duration of the project with a stipend of approx. £15K per annum for eligible students.


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