The horse is possibly the only mammal that has the ability to increase its heart rate to more than six times resting levels and yet remain within normal physiological compliance. The inherent ability of the equine heart to cope with such drastic changes requires complex electrical and molecular compliance. The mechanisms for such compliance is not well understood and the present work will entail the application and extension of our current understanding on cardiac compliance in mice and humans. Additionally, an understanding of cardiac compliance will form the basis of developing strategies for the prediction, management and prevention of cardiovascular abnormalities commonly seen human athletes.
The successful candidate will be involved in a multidisciplinary research project in collaboration with the Surrey and Cambridge. The candidate will be exposed to a range of electrophysiological (in-vivo electrocardiogram recordings, Langendorff perfused setups, sharp electrode experiments, loose patch techniques, and confocal microscopy) and molecular (western blots, qPCR, ELISA) and histological techniques.
This project is due to commence in October 2021.
This is an interdisciplinary project in electrophysiology and molecular biology. Undergraduates with a degree in Biological Sciences or related subjects are welcomed as long as they have a strong interest in electrophysiology and molecular biology. Medical and veterinary graduates are encouraged to apply. A Master’s degree in related subject is desirable and previous experience in electrophysiology work is useful but not essential.
How to apply
Please apply for this PhD through the Veterinary Medicine PhD programme page. Applicants are invited to contact Dr. Jeevaratnam ([Email Address Removed]) to discuss the project informally prior to making an application.