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PhD Studentship Opportunity in Systems Biology of Cell Cycle Control

  • Full or part time
  • Application Deadline
    Friday, January 31, 2020
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

A PhD Studentship is available in the Systems Biology group of Dr. Matteo Barberis at the University of Surrey, to construct, analyse and simulate mathematical models of the molecular regulatory networks underlying a timely cell division cycle. Many distinct cellular processes need to occur at definite times relative to one another; indeed, networks controlling cell division shall guarantee alternation between incompatible cell cycle phases. We are focusing on the balance of cellular activators and inhibitors, which can modulate the cell cycle network, and we have recently discovered molecular designs that are responsible for its precise timing (e.g. Linke et al. 2017, Nature NPJ Systems Biology and Applications, 3, 7). In particular, we aim to unravel principles of designs and patterns that can emerge from the complex network of interactions, which are responsible for a timely cell cycle.

We are seeking an enthusiastic and highly-motivated scientist with a Masters degree (or equivalent qualification) in systems biology, computational biology, biophysics, mathematical biology, engineering, control theory or closely aligned disciplines. Experience with at least two programming languages, such as Matlab, Mathematica and Python, and experience with software for simulation and analysis of biochemical networks, such as Copasi, is essential. Experience in systems biology projects and/or in mathematical modelling and analysis of biophysical/biochemical systems (e.g. deterministic modelling, nonlinear dynamics, parameter fitting, properties of dynamical systems across high-dimensional parameter spaces) is essential. Knowledge of methods for modelling biological networks and skills in bioinformatics, e.g. computational approaches to analyse ChIP-exo data and/or maintenance/development of a community database, are a great plus. Knowledge of biochemistry and molecular biology is appreciated.

Fluent English both spoken and written is required. Excellent communication skills, capacity to work in autonomy and in a team, and enthusiasm for exposure to a diversity of scientific projects, are essential. Participation in national and international collaborations is expected.

This is a 3 year project, commencing in April 2020.

Entry requirements:
Applicants will need to have a masters in a relevant subject. Non-native speakers of English, who did not study in an English-speaking country, will be required to have IELTS score 7.5 or above with 7.0 in each individual category.

How to apply:
Applicants will need to apply through the Biosciences and Medicine PhD Course page: https://www.surrey.ac.uk/postgraduate/biosciences-and-medicine-phd#apply. Please include a cover letter/personal statement, a detailed CV with Bachelors/Masters grades and publication list, and contact details for at least two references. Interviews will start in February until the post is filled.

Funding Notes

This is a fully funded project with an annual stipend of approx £15,000.

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