Spin physics is central to the radical pair mechanism of the avian compass and is probably the fastest-growing field within quantum biology. However, progress with the avian compass model has been slow, dogged by the difficulties of working with birds as the standard in vivo model. The system described here appears to have quantum biology features that can be measured by one of the simplest measurements in biology: antibiotic resistance. Moreover, the live model system will be in E. coli, which is the simplest and most easily manipulated model organism and the one of which vastly more is known than any other organism.
The project that will be conducted within the Quantum Biology Doctoral Training Centre will study the radical pair mechanism that has been proposed to be responsible for the action of the antibiotic isoniazid. Isoniazid (INH) is one of the key drugs for treatment of tuberculosis, which affects about 10 million in the world today and kills about 1.5 million of them annually. The target of isoniazid is the catalase-peroxidase, KatG. Complexes of KatG:INH complexes have been crystallized and structure determined (Kamachi et al., 2015) allowing the construction of detailed molecular models of the RPM of INH action. This project will use these resources to test various models of RPM action of isoniazid.
Supervisors: Professor Johnjoe McFadden and Dr Youngchan Kim
This is a 3 year project starting in January 2022. Funding is available for the first 24 months.
Find out more about the Leverhulme Quantum Biology Doctoral Training Centre.
BSc/Masters, experimental physical scientist/chemist.
English language requirements: IELTS minimum 6.5 overall with 6.0 in Writing, or equivalent.
How to apply
Applications should be submitted via the Biosciences and Medicine PhD programme page on the "Apply" tab.
Please state clearly the studentship project at you would like to apply for.