Dr Y Wang, Dr A Steele
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Autophagy, a process by which cells respond to starvation and other stresses by degrading damaged or unneeded parts to produce energy, is required to provide survival signals for tumour cells to achieve optimal growth, particularly those harbouring RAS mutations. Autophagy inhibition has thus been suggested as a viable strategy for targeting RAS-driven tumours. This project aims to understand the triggers and players within the autophagy machinery that are involved in oncogenic RAS-induced invasive behaviour, with a view to seeking biomarkers of aggressive disease and opportunities for clinical intervention. It will utilise molecular and cell biology approaches, along with advanced imaging techniques in combination with siRNA screens.
Funding Notes
The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at current research council rates of £ 14,057 per annum.
Due to funding restrictions this position is only open to UK/EU applicants.
References
References:
1. Wang Y, et al: Autophagic activity dictates the cellular response to oncogenic RAS. Proc Natl Acad Sci U S A 2012, 109(33):13325-13330.
2. Wang Y, et al: Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene 2010, 29(33):4658-4670.
3. Wang Y, et al: ASPP2 controls epithelial plasticity and inhibits metastasis through beta-catenin-dependent regulation of ZEB1. Nat Cell Biol 2014, 16(11):1092-1104.
Applications for an MPhil/PhD in Biological Sciences should be submitted online at:
https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201516
Please place Yihua Wang’s name in the field for proposed supervisor.
General enquiries should be made to Dr Yihua Wang at Yihua.wang@soton.ac.uk. Any queries on the application process should be made to pgafnes@soton.ac.uk
After the deadline, all applications will be considered together and selected candidates will be invited for an interview.
The University of Southampton and the Centre for Biological Sciences both hold an Athena Swan Bronze Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.
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