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PhD studentship - Targeting a novel chaperone to block prostate cancer bone metastasis.

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  • Full or part time
    Prof M Briggs
    Dr J Munkley
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Number of awards

Start date and duration
28 September 2020. 3 Year PhD

Prostate cancer is the most common cancer in males causing ~12,000 deaths each year in the UK. 80% of men with advanced disease develop painful and incurable bone metastasis. The 5-year survival rate for men with bone metastasis is only 29% and so new treatments are urgently needed to improve patient quality of life and survival rates.

The mechanisms that initiate relapse and bone metastasis in prostate cancer are poorly understood and our exciting unpublished data suggests that a novel chaperone could play a key role in this.

Using complementary expertise at Newcastle University, this PhD project will test its role in prostate cancer growth and bone metastasis and identifying the mechanisms involved. Specifically, the student will be trained in genome editing, cutting-edge models to study the bone metastatic niche, advanced imaging techniques and pre-clinical models of advanced prostate cancer. By the end of the project we expect to have obtained robust pre-clinical data, supporting the use of targeted therapies to prevent/inhibit prostate cancer bone metastasis which could be translated into human therapy.

Newcastle University

Name of supervisor(s)
Professor Michael Briggs, Dr Jennifer Munkley, Dr Ella Dennis (Biosciences Institute -

Eligibility Criteria
You must have, or expect to achieve, at least a 2:1 Honours degree in Biochemistry, Biomedicine, Genetics or a related area. A further qualification such as an MSc or MRes is advantageous.

This award is available to UK/EU and international applicants.

To study this course you need to meet the following English Language requirements:
IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).

How to apply
You must apply through the University’s online postgraduate application system

Only mandatory fields need to be completed. However, you will need to include the following information:

-insert the programme code 8300F* in the programme of study section
-select ‘PhD in the Faculty of Medical Sciences – Biosciences’ as the programme of study
-insert the studentship code bi019 in the studentship/partnership reference field
-attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code bi019 and state how your interests and experience relate to the project
-attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications

* The online application system will only allow one application using the programme code 8300F. If you are applying for TWO or more projects using that code you will need to email our Postgraduate Admissions Service ([Email Address Removed]) with the following information:

-your application number (from the first project application that you submitted online)
-the second studentship code and its corresponding title
-a two page covering letter for the second project

Our Postgraduate Admissions Service will then forward this information to the relevant selector in the Faculty of Medical Sciences.

Professor Michael Briggs: [Email Address Removed]

Funding Notes

100% of UK/EU tuition fees paid and annual living expenses of £15,285 (full award). Successful international candidates will be required to make up the difference between the UK/EU fees and international fees.

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