Coventry University Featured PhD Programmes
University of Edinburgh Featured PhD Programmes
University College London Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
University of East Anglia Featured PhD Programmes

PhD thesis in physiologically based pharmacokinetic modeling of long-acting injectable antiretroviral drugs: Basel, Switzerland


About This PhD Project

Project Description

A fully funded PhD position (100%) is available in the Division of Infectious Diseases & Hospital Epidemiology at the University Hospital of Basel. The project aims to develop physiologically based pharmacokinetic (PBPK) models to simulate dosing requirements of long-acting intramuscular antiretroviral drugs in special populations and to manage drug-drug interactions with concurrent medications.
The PBPK approach uses in vitro drug data (i.e. physicochemical characteristics, intrinsic clearance, and intestinal permeability) and a mathematical description of drug absorption, distribution, metabolism and elimination (ADME) to predict the pharmacokinetics in a virtual population.
This research project is of particular clinical importance, as it will provide guidance on dosing requirements in special populations, which were not evaluated comprehensively during drug development but which may also benefit from this novel treatment paradigm aiming to improve the chances of life-long maintenance of HIV suppression. In addition, this project will provide a comprehensive knowledge of factors influencing intramuscular drug disposition and improve the knowledge on drug-drug interactions with this route of administration.

You are a highly motivated young scientist with an above-average degree (MSc or equivalent) in pharmacy, natural science or mathematics. In addition, you have knowledge about relevant pharmacological concept. Experience in modelling will be an advantage
This position is also open to candidates from the European Union and North America. The working language is English. German skills, although helpful, are not essential. Basel is a highly attractive city with a multinational population.

Application/contact
Please send one PDF file including CV with academic transcripts, publications/ presentations at conferences, three academic references as well as a letter of motivation to:
Prof. C. Marzolini: and F. Stader:
Applications will be considered until December 31, 2019. The position is available from April 2020.
Please note that there will be no follow-up correspondence for applications that do not fulfill the position requirements.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.