A fully funded PhD position (100%) is available in the Division of Infectious Diseases & Hospital Epidemiology at the University Hospital of Basel. The project aims to develop physiologically based pharmacokinetic (PBPK) models to simulate dosing requirements of long-acting intramuscular antiretroviral drugs in special populations and to manage drug-drug interactions with concurrent medications. The PBPK approach uses in vitro drug data (i.e. physicochemical characteristics, intrinsic clearance, and intestinal permeability) and a mathematical description of drug absorption, distribution, metabolism and elimination (ADME) to predict the pharmacokinetics in a virtual population. This research project is of particular clinical importance, as it will provide guidance on dosing requirements in special populations, which were not evaluated comprehensively during drug development but which may also benefit from this novel treatment paradigm aiming to improve the chances of life-long maintenance of HIV suppression. In addition, this project will provide a comprehensive knowledge of factors influencing intramuscular drug disposition and improve the knowledge on drug-drug interactions with this route of administration.
You are a highly motivated young scientist with an above-average degree (MSc or equivalent) in pharmacy, natural science or mathematics. In addition, you have knowledge about relevant pharmacological concept. Experience in modelling will be an advantage This position is also open to candidates from the European Union and North America. The working language is English. German skills, although helpful, are not essential. Basel is a highly attractive city with a multinational population.
Application/contact Please send one PDF file including CV with academic transcripts, publications/ presentations at conferences, three academic references as well as a letter of motivation to: Prof. C. Marzolini: [email protected] and F. Stader: [email protected] Applications will be considered until December 31, 2019. The position is available from April 2020. Please note that there will be no follow-up correspondence for applications that do not fulfill the position requirements.