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  [PhD with placement at GSK] Unleashing the Full Potential of Electrosynthesis at Scale: "Go Big or Go Home"


   Department of Pharmaceutical, Chemical and Environmental Sciences

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  Prof Kevin Lam  No more applications being accepted  Funded PhD Project (European/UK Students Only)

About the Project

Although oxidation reactions are common in organic chemistry, their implementation on a larger scale is often challenging due to cost and safety concerns associated with the use of large amounts of oxidants. 

In the last century, electrosynthesis has proven to be able to perform redox transformations under unprecedented mild and green conditions.

Therefore, in this project, in collaboration with GSK, we will develop unique approaches to develop novel anodic oxidation reactions relevant to the pharmaceutical industry. We will focus on developing methods that are robust and have the potential to be scaled up to process scale.

We are now looking for highly motivated PhD students to join our team and further explore the synthetic potential of organic electrosynthesis.

The review of applications and selection of the ideal candidate will start immediately. You are therefore strongly encouraged to apply as soon as possible. The selected PhD candidate will benefit from a placement at GSK.

Chemistry (6)

Funding Notes

The grant will cover the Home (UK, EU (pre)-settled and Ireland) tuition fees and offer a stipend in line with UKRI.

References

Russo, C.; Leech, M. C.; Walsh, J. M.; Higham, J. I.; Giannessi, L.; Lambert, E.; Kiaku, C.; Poole, D. L.; Mason, J.; Goodall, C. A. I.; Devo, P.; Giustiniano, M.; Radi, M.; Lam, K. eHydrogenation: Hydrogen‐free Electrochemical Hydrogenation. Angewandte Chemie 2023, e202309563
Lam, K.; Wheelhouse, K. M. P. Unleashing the Potential to Electrify Process Chemistry: From Bench to Plant. Org. Process Res. Dev. 2021, 25 (12), 2579–2580. https://doi.org/10.1021/acs.oprd.1c00434.
Leech, M. C.; Petti, A.; Tanbouza, N.; Mastrodonato, A.; Goodall, I. C. A.; Ollevier, T.; Dobbs, A. P.; Lam, K. Anodic Oxidation of Aminotetrazoles: A Mild and Safe Route to Isocyanides. Org. Lett. 2021, https://doi.org/10.1021/acs.orglett.1c03475.
Quertenmont, M.; Toussaint, F. C.; Defrance, T.; Lam, K.; Markó, I. E.; Riant, O. Continuous Flow Electrochemical Oxidative Cyclization and Successive Functionalization of 2-Pyrrolidinones. Org. Process Res. Dev. 2021, 25, 2631–2638 https://doi.org/10.1021/ acs.oprd.1c00188.

Where will I study?

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