About the Project
Photochemically induced dynamic nuclear polarisation (photoCIDNP) utilises a spin-state selective photochemical reaction between a suitable dye and the molecule of interest to produce nuclear spin polarisation via hyperfine modulations of a spin-correlated radical pair. This approach allows repetition of the experiment via multiple illuminations enabling both signal averaging and extension to multidimensional experiments. The only requirement is a suitable dye, e.g. a flavin, a high intensity illumination source and the formation of a spin-correlated radical pair. Recently, we have begun an EPSRC funded project (EP/P015735/1) to develop photoCIDNP as a sensitivity enhancement technique for small molecule structure elucidation, focusing on improvements in heteronuclear correlation experiments.
This project will focus on the development of a suit of homonuclear correlation experiments (i.e. 1H-1H corelations) applicable to structure elucidation, such as COSY, NOESY etc, including characterising the improvements in limit of detection and/or time saving available. These experiments form part of the routine package of spectroscopic experiments performed when undertaking the determination of an unknown structure. The project will have three distinct aims:
1. Develop photochemically enhanced variants of standard homonuclear correlation experiments. Modifications such as the combined COSY-NOESY experiment (termed COCONOESY) will also be explored in order to gain further information from a single experiment.
2. Incorporate state-of-the-art data collection strategies such as non-uniform sampling and ultrafast acquisition schemes. In combination with photochemical enhancement these techniques will greatly reduce the amount of time required to obtain the data, improving experimental throughput
3. Application of these homoPASSE experiments to structure elucidation and low concentration impurity identification
This project will utilise the second generation LED illumination setup currently under construction in the Day laboratory.
How to apply:
Please submit a formal application using our online application system at http://www.sussex.ac.uk/study/phd/apply, including a CV, degree transcripts and certificates, statement of interest (clearly stating supervisor’s name and the project title) and names of two academic referees. On the application system use Programme of Study – PhD Chemistry.
For enquiries about the application process contact Anna Izykowska ([Email Address Removed])
For enquiries about the project contact Dr Iain Day ([Email Address Removed])
The EPSRC award covers Home/EU PhD fees, a tax-free living expenses at Research Council UK rates (currently £14,553 per annum) and research/training expenses for 3.5 years.
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