Healthcare-associated infections cause life-threatening harm to patients, incur major additional treatment costs and is high NHS priority. Patients with kidney disease are especially susceptible to harm associated with dialysis catheter use. These catheters, essential to the delivery of life-sustaining dialysis treatment (70-75% of incident and 30-40% of prevalent dialysis patients and higher in developing nations)) are a major driver of bloodstream infection and increased mortality in patients receiving dialysis. Antibiotic
locks, systemic and topical antibiotics are the mainstay of management of both empiric and definitive infections. In an era of global emergency of infections with drug-resistant organisms, non-pharmacological approach to managing catheter infections would be game-changing.
Ultraviolet (UV) light has been proposed as an alternative to antibiotics. UV-C band of wavelength 250-270 nm is considered germicidal. Previous studies have demonstrated the feasibility of delivering UV-light into the lumen by exposing the catheter hubs to light – emitting diodes. But this technique may not result in effective irradiation of the entire length of these catheters. Fibre-optics for delivery of UV light has been proposed, but the precise dose and duration of UV delivery for germicidal effect, optimal method for identifying colonised biofilms in explanted vascular catheters from patients with and without bacteraemia, and effect on vascular endothelium are unknown. We propose to address these within the current project to develop a novel therapy using a novel laboratory model of haemodialysis catheters.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience are particularly encouraged to apply.
How To Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”