This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
There is variation between individuals in obesity-related traits. Our current research shows that epigenetic signals may complement genetic information in explaining such variation. This project will identify individual obesity-related loci that are the target of epigenetic modification. We will ask if the same loci contribute to both genetic and epigenetic effects on obesity and whether these signals act independently or through interactions. The project will use computational analyses of large scale population data on genomic and epigenetic variation in Scottish cohorts and thus will suit a student with in interest in computational, statistical or bioinformatic analyses of big data.