About the Project
The group studies human-specific pathogens that are exquisitely adapted to their host. Our overall aim is to understand the mechanistic basis of host:pathogen interactions, and the acquisition and spread of AMR.
The project will focus on plasmid-borne AMR in Neisseria gonorrhoeae and Shigella spp. Plasmids are selfish elements which parasitise their bacterial hosts while providing potentially beneficial traits for the host. We have undertaken extensive phylogenetic analysis of AMR plasmids in these important human pathogens, and work will define the basis of plasmid maintenance and transfer in the respective hosts. The student will undertake genetic screens for genes involved in plasmid biology, and biochemical studies to define the function of key factors in plasmid maintenance. This will be combined with bioinformatics of large genome sequence datasets to identify polymorphisms in plasmids and their hosts which affect their relationship.
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