University of Oxford Featured PhD Programmes
University of Leeds Featured PhD Programmes
University of Oxford Featured PhD Programmes
Prof C Tang Friday, January 08, 2021 Competition Funded PhD Project (Students Worldwide)

About the Project

The acquisition of plasmids is fundamental to the evolution of virulence and antimicrobial resistance (AMR) in many bacteria.
The group studies human-specific pathogens that are exquisitely adapted to their host. Our overall aim is to understand the mechanistic basis of host:pathogen interactions, and the acquisition and spread of AMR.
The project will focus on plasmid-borne AMR in Neisseria gonorrhoeae and Shigella spp. Plasmids are selfish elements which parasitise their bacterial hosts while providing potentially beneficial traits for the host. We have undertaken extensive phylogenetic analysis of AMR plasmids in these important human pathogens, and work will define the basis of plasmid maintenance and transfer in the respective hosts. The student will undertake genetic screens for genes involved in plasmid biology, and biochemical studies to define the function of key factors in plasmid maintenance. This will be combined with bioinformatics of large genome sequence datasets to identify polymorphisms in plasmids and their hosts which affect their relationship.





Funding Notes

4 Year DPhil Prize Studentships cover full University fees, a tax free enhanced stipend of ~£17,285 pa, and up to £5,300 pa for research costs and travel. The competition is open to applicants from all countries. See View Website for full details and to apply.

References

https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa003/5804211
https://www.nature.com/articles/s41579-018-0031-2
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