Platelets are tiny circulating blood cells which prevent bleeding from damaged blood vessels (haemostasis) by becoming active at the site of injury. In addition to this crucial role, platelets can be activated inappropriately (thrombosis) leading to heart attack or stroke. Platelets also contribute to the progression of other diseases such as inflammation, cancer, or diabetes through the secretion of bioactive substances and microparticles which influence the activity of many different cell types.
Thrombotic complications are commonly seen in cancer patients and are a leading cause of death in these patients. This exciting new project aims to explore how platelets regulate cancer cell activity. The successful student will investigate how platelet-released substances interact with receptors on the surface of cancer cells, how this leads to the formation of tumour cell-platelet aggregates and will explore if this can be targeted to reduce cancer metastasis and develop better therapies.
This project will equip the student with skills in a wide range of techniques including the use of specialist tests of platelet function, cell migration, cell and molecular biology assays, mass spectrometry and microscopy.
Supervisors: Dr Lisa Holbrook, Dr Lewis
Entry requirements
Open to UK and EU students starting in July 2023.
You will need to meet the minimum entry requirements for our PhD programme.
Applicants should have a first-class or upper second-class honours or equivalents in Biochemistry, Biomedical Sciences, Biomedical Engineering, Biological Sciences, Physiology or similar subjects.
Practical experience of cell biology, platelet or cancer cell biology is desirable but not essential.
How to apply
Applicants are encouraged to contact Dr Lisa Holbrook to discuss the project informally prior to applying.
Applications should be submitted via the https://www.surrey.ac.uk/postgraduate/veterinary-medicine-and-science-phd programme page (N.B. Please select the July 2023 start date when applying).
When completing your application, in place of a research proposal, please provide a brief motivational document (1 page maximum) which specifies:
· the project title, reference number PGR-2223-034 LMH01 and principal supervisor name
· an explanation of your motivations for wanting to study for a PhD
· an explanation of your reasons for selecting the project you have chosen
Additionally, to complete a full application, you MUST also email a copy of your CV and 1-page motivational document directly to the relevant project principal supervisor. Due to short turnaround times for applicant shortlisting, failure to do this may mean that your application is not considered.
Please note that online interviews for shortlisted applicants are expected to take place in late March/early April.
Reference No: LMH01
Continue with Facebook
