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Pluripotent cell-derived mesenchymal stem cells: biology and therapy

  • Full or part time
  • Application Deadline
    Thursday, February 28, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

PhD studentship in Biomedical Sciences (to be admitted in mid-August 2019)
University of Macau is the flagship public university in Macau, rapidly developing for high-quality education and groundbreaking research with English as its working language. The Faculty of Health Sciences at the University is staffed with outstanding researchers recruited from all over the world and equipped with state‐of‐the‐art facilities. As the associate dean (research) of the faculty, Professor Ren-He XU is seeking highly motivated PhD candidates to perform stem cell research.
The Xu laboratory focuses on study of mesenchymal stem cells differentiated from human embryonic stem cells and their application in treatment of autoimmune and inflammatory diseases. Professor Xu has extensive research experience with many articles published in high-profile journals and near 6,000 citations. For details, please visit https://fhs.umac.mo/staff/academic-staff/xu-ren-he/.
Applicants must hold a bachelor or master degree in relevant areas of biomedical sciences. Previous experience in stem cell and molecular biology is preferred. Candidates recruited from high-ranking universities can also apply for the “UM Macao PhD Scholarship” (MPDS) which offers annual stipend up to MOP240,000 (about USD30,000) for a period up to 4 years. Please visit Graduate School’s website (https://www.umac.mo/grs/en/index.php) for details of the MPDS.
For application, please contact Professor Ren-He XU at .
Application Deadline
28 February 2019

Normative Study Period
4 years

Funding Notes

Macau Science and Technology Development Fund (FDCT) #095-2017-A2
Macau Science and Technology Development Fund (FDCT) #028-2015-A1
University of Macau Multi-Year Research Grant (MYRG) #2017-00124-FHS
University of Macau Faculty of Health Sciences Internal Grant 2017-02
University of Macau MYRG #2016-00070-FHS
University of Macau Faculty of Health Sciences Internal Grant 2018-03
University of Macau MYRG #2015-00169-FHS

References

Park, J.W., Yang, J., and Xu, R.-H. PAX6 alternative splicing and corneal development. Stem Cells & Dev. Jan. 2018.
Kurtz, A., Seltmann, S., ...., Xu, R.-H. A standard nomenclature for referencing and authentication of pluripotent stem Cells. Stem Cell Reports 10(1):1-6, Jan. 2018.
Jiang, B., Yan, L., Miao, Z., Li, E.-Q., Wong, K.H., and Xu, R.-H. Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation. Biomaterials 133:275-86, 2017.
Zheng, D., Wang, X., and Xu, R.-H. One stone for multiple birds: generating universally compatible human embryonic stem cells. Stem Cells 34(9):2269-75, 2016.
Wang, X., Lazorchak, A.S., Song, L., Li, E., Jiang, B., Zhang, Z., and Xu, R.-H. Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage. Stem Cells 34(2):380-91, 2016.
Wang, X., Kimbrel, E.A., ..., and Xu, R.-H. Human ES cell-derived MSC outperform bone marrow MSC in the treatment of an EAE model of multiple sclerosis. Stem Cell Reports 3(1):115-130, 2014.
Martins-Taylor, K., Nisler, B.S., ..., and Xu, R.-H. Recurrent copy number variations in human induced pluripotent stem cells. Nature Biotechnol. 29(6):488-91, 2011.
Xu, R.-H., Sampsell-Barron, T.L., ..., and Thomson, J.A. NANOG is a direct target of TGFb/Activin mediated SMAD signaling in human ES cells. Cell Stem Cell 3(2):196-206, 2008.
Xu, R.-H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., and Thomson, J.A. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nature Methods 2(3):185-190, 2005.
Xu, R.-H., Chen, X., Li, D.S., Li, R., Addicks, G.C., Glennon, C., Zwaka, T.P., and Thomson, J.A. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nature Biotechnol. 20(12):1261-4, 2002.

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