Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact at The University of Manchester on FindAPhD.com

Dr J Barber, Dr Daniel Scotcher, Prof A Rostami Applications accepted all year round Self-Funded PhD Students Only

Email institution

Institution website

Add
to
shortlist

Remove
from
shortlist

Email institution

Manchester United Kingdom Analytical Chemistry Biochemistry Pharmaceutical Chemistry Pharmacology Pharmacy

Faculty of Biology, Medicine and Health, The University of Manchester

About the Project

Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs).

In this project, we will use state-of-the-art proteomic techniques to quantify aldehyde oxidase and other cytosolic enzymes, and, in particular, to assess polymorphisms that can affect drug metabolism. We will then populate models of drug metabolism with quantitative information on both wild-type and variant enzymes and determine the effects of polymorphism on drug metabolism and hence optimum drug dosage. The endpoint of the project is a model that can be used to bring clinical benefit to patients.

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

Funding Notes

Applications are invited from self-funded students. This project has a Band 3 fee. Details of our different fee bands can be found on our website (View Website)

References

Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine
N Couto ZM Al-Majdoub, S Gibson, PJ Davies, B Achour, MD Harwood, G Carson, J Barber, A Rostami-Hodjegan, G Warhurst,
Drug Metab. Dispos. 2020, 48: 245-254.
Characterization of CYP2B6 K262R allelic variants by quantitative allele-specific proteomics using a QconCAT standard
J Barber, MR Russell, A Rostami-Hodjegan, B Achour, J Pharm. Biomed. Analysis 2020, 178: 112901.
Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients
ZM Al-Majdoub, H Al Feteisi, B Achour, S Warwood, S Neuhoff, A Rostami-Hodjegan, J Barber, Molecular Pharmaceutics 2019, 16: 1220-1233

Email Now

Recipient *

Your first name *

Your last name *

Your telephone number

Your e-mail address *

Your CV (2MB limit)

Where are you currently living? *

Your nationality *

Insert previous message

Your message * (please edit as appropriate)

You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

* required field

Send a copy to me for my own records

The information you submit to The University of Manchester will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.